285703

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2123414..2123928 Replicon chromosome
Accession NZ_LN854556
Organism Staphylococcus aureus strain B155

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag SABB155_RS10665 Protein ID WP_054190442.1
Coordinates 2123414..2123623 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag SABB155_RS10670 Protein ID WP_000138934.1
Coordinates 2123635..2123928 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SABB155_RS10645 2118922..2120280 - 1359 WP_054190439.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SABB155_RS10650 2120295..2121365 - 1071 WP_054190440.1 D-alanine--D-alanine ligase -
SABB155_RS10655 2121683..2122885 + 1203 WP_054190441.1 rod shape-determining protein RodA -
SABB155_RS10660 2123149..2123286 - 138 WP_000828354.1 hypothetical protein -
SABB155_RS10665 2123414..2123623 - 210 WP_054190442.1 heavy-metal-associated domain-containing protein Toxin
SABB155_RS10670 2123635..2123928 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
SABB155_RS10675 2124098..2125582 + 1485 WP_054190443.1 cardiolipin synthase -
SABB155_RS10680 2125610..2126257 + 648 WP_001187616.1 HD domain-containing protein -
SABB155_RS10685 2126837..2127709 - 873 WP_000725800.1 membrane protein insertase YidC -
SABB155_RS10690 2127795..2128436 - 642 WP_054190444.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7830.77 Da        Isoelectric Point: 4.1008

>T285703 WP_054190442.1 NZ_LN854556:c2123623-2123414 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISSMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKILF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT285703 WP_000138934.1 NZ_LN854556:c2123928-2123635 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References