285702

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2103673..2104202 Replicon chromosome
Accession NZ_LN854556
Organism Staphylococcus aureus strain B155

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag SABB155_RS10575 Protein ID WP_000621175.1
Coordinates 2103673..2104035 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag SABB155_RS10580 Protein ID WP_000948331.1
Coordinates 2104032..2104202 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SABB155_RS10550 2100651..2101421 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
SABB155_RS10555 2101396..2101875 - 480 WP_054190427.1 anti-sigma B factor RsbW -
SABB155_RS10560 2101877..2102203 - 327 WP_001052491.1 anti-sigma factor antagonist -
SABB155_RS10565 2102322..2103323 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
SABB155_RS10575 2103673..2104035 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SABB155_RS10580 2104032..2104202 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
SABB155_RS10585 2104287..2105435 - 1149 WP_054190429.1 alanine racemase -
SABB155_RS10590 2105501..2105860 - 360 WP_000581197.1 holo-ACP synthase -
SABB155_RS10595 2105864..2106355 - 492 WP_054190430.1 PH domain-containing protein -
SABB155_RS10600 2106342..2107925 - 1584 WP_054190431.1 PH domain-containing protein -
SABB155_RS10605 2107918..2108397 - 480 WP_054190432.1 hypothetical protein -
SABB155_RS10610 2108606..2109166 - 561 WP_054190433.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T285702 WP_000621175.1 NZ_LN854556:c2104035-2103673 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT285702 WP_000948331.1 NZ_LN854556:c2104202-2104032 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References