285686

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1532274..1532942 Replicon chromosome
Accession NZ_LN847353
Organism Streptococcus pneumoniae strain A66

Toxin (Protein)


Gene name hicA Uniprot ID A0A0B7M7X4
Locus tag A66_RS07945 Protein ID WP_001132284.1
Coordinates 1532763..1532942 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag A66_RS07940 Protein ID WP_000961810.1
Coordinates 1532274..1532726 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A66_RS07915 1528164..1528907 - 744 WP_001188205.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
A66_RS07920 1528909..1529859 - 951 WP_050212241.1 50S ribosomal protein L11 methyltransferase -
A66_RS07925 1529997..1530425 - 429 WP_053039728.1 NUDIX hydrolase -
A66_RS07930 1530427..1531494 - 1068 WP_053039729.1 M50 family metallopeptidase -
A66_RS07935 1531513..1531983 - 471 WP_000257104.1 DUF3013 family protein -
A66_RS07940 1532274..1532726 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A66_RS07945 1532763..1532942 - 180 WP_001132284.1 type II toxin-antitoxin system HicA family toxin Toxin
A66_RS07950 1533079..1533258 - 180 WP_001048906.1 hypothetical protein -
A66_RS07955 1533423..1533662 - 240 Protein_1540 hypothetical protein -
A66_RS07960 1533932..1535203 + 1272 WP_001113214.1 replication-associated recombination protein A -
A66_RS07970 1535748..1537067 - 1320 WP_000502562.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T285686 WP_001132284.1 NZ_LN847353:c1532942-1532763 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL

Download         Length: 180 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT285686 WP_000961810.1 NZ_LN847353:c1532726-1532274 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7M7X4

Antitoxin

Source ID Structure
AlphaFold DB G0IC64

References