Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1072991..1073489 Replicon chromosome
Accession NZ_LN847353
Organism Streptococcus pneumoniae strain A66

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag A66_RS05525 Protein ID WP_001809704.1
Coordinates 1072991..1073245 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag A66_RS05530 Protein ID WP_000208080.1
Coordinates 1073247..1073489 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A66_RS05520 1071045..1072916 - 1872 WP_053039627.1 Eco57I restriction-modification methylase domain-containing protein -
A66_RS05525 1072991..1073245 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A66_RS05530 1073247..1073489 - 243 WP_000208080.1 hypothetical protein Antitoxin
A66_RS05535 1073580..1074389 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
A66_RS05540 1074391..1075740 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
A66_RS05545 1075733..1076437 - 705 WP_053039628.1 response regulator transcription factor -
A66_RS05550 1076493..1077668 - 1176 WP_000886145.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T285685 WP_001809704.1 NZ_LN847353:c1073245-1072991 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT285685 WP_000208080.1 NZ_LN847353:c1073489-1073247 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References