Detailed information of TA system TA285684

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 913596..914833
• Replicon: chromosome
• Accession: NZ_LN847353
• Organism: Streptococcus pneumoniae strain A66

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: A66_RS04780
• Protein ID: WP_000405627.1
• Coordinates: 914072..914833 (+)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: A66_RS04775
• Protein ID: WP_000579614.1
• Coordinates: 913596..914072 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A66_RS04750	908669..909523	+	855	WP_000900015.1	ADP-ribosylglycohydrolase family protein	-
A66_RS04755	909635..910519	+	885	WP_053039593.1	diacylglycerol kinase family lipid kinase	-
A66_RS04760	910682..912421	+	1740	WP_000423465.1	glycoside hydrolase family 13 protein	-
A66_RS04770	912696..913151	+	456	WP_053039843.1	hypothetical protein	-
A66_RS04775	913596..914072	+	477	WP_000579614.1	helix-turn-helix domain-containing protein	Antitoxin
A66_RS04780	914072..914833	+	762	WP_000405627.1	zeta toxin family protein	Toxin
A66_RS11005	914861..915637	+	777	Protein_924	hypothetical protein	-
A66_RS04795	915565..916017	+	453	WP_078169748.1	hypothetical protein	-
A66_RS04800	916840..917201	+	362	Protein_926	hypothetical protein	-
A66_RS04805	917211..917576	+	366	WP_000263055.1	MobC family plasmid mobilization relaxosome protein	-
A66_RS12170	917563..919427	+	1865	Protein_928	relaxase/mobilization nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	891074..1013037	121963

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 29078.03 Da
• Isoelectric Point: 6.7759

>T285684 WP_000405627.1 NZ_LN847353:914072-914833 [Streptococcus pneumoniae]
MEIQYYTDSEFKHALTRNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHHLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKETAQLLKSKGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Nucleotide

• Length: 762 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18236.67 Da
• Isoelectric Point: 4.3462

>AT285684 WP_000579614.1 NZ_LN847353:913596-914072 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp