Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 326357..326962 Replicon chromosome
Accession NZ_LN847264
Organism Pseudomonas sp. CCOS 191

Toxin (Protein)


Gene name PumA Uniprot ID A0A0F7Y1Z8
Locus tag CCOS191_RS01580 Protein ID WP_046853797.1
Coordinates 326357..326647 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CCOS191_RS01585 Protein ID WP_046853798.1
Coordinates 326657..326962 (+) Length 102 a.a.

Genomic Context

CCOS191_RS01565CCOS191_RS01580CCOS191_RS01585CCOS191_RS01560CCOS191_RS01570CCOS191_RS01575CCOS191_RS01595CCOS191_RS01600CCOS191_RS01605
Location: 323177..324562 (1386 bp)
Type: Others
Protein ID: WP_046853794.1
Location: 326357..326647 (291 bp)
Type: Toxin
Protein ID: WP_046853797.1
Location: 326657..326962 (306 bp)
Type: Antitoxin
Protein ID: WP_046853798.1
Location: 321797..322570 (774 bp)
Type: Others
Protein ID: WP_046853793.1
Location: 324649..325092 (444 bp)
Type: Others
Protein ID: WP_046853795.1
Location: 325182..326063 (882 bp)
Type: Others
Protein ID: WP_172670913.1
Location: 327242..327514 (273 bp)
Type: Others
Protein ID: WP_011536185.1
Location: 327511..328578 (1068 bp)
Type: Others
Protein ID: WP_046853799.1
Location: 328575..330824 (2250 bp)
Type: Others
Protein ID: WP_046853800.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CCOS191_RS01560321797..322570-774WP_046853793.1ABC transporter ATP-binding protein-
CCOS191_RS01565323177..324562+1386WP_046853794.1GABA permease-
CCOS191_RS01570324649..325092-444WP_046853795.1hypothetical protein-
CCOS191_RS01575325182..326063-882WP_172670913.1polyphosphate kinase 2-
CCOS191_RS01580326357..326647+291WP_046853797.1type II toxin-antitoxin system RelE/ParE family toxinToxin
CCOS191_RS01585326657..326962+306WP_046853798.1putative addiction module antidote proteinAntitoxin
CCOS191_RS01595327242..327514-273WP_011536185.1oxidative damage protection protein-
CCOS191_RS01600327511..328578-1068WP_046853799.1A/G-specific adenine glycosylase-
CCOS191_RS01605328575..330824-2250WP_046853800.1AsmA family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--307248..33374426496


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-90)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10898.73 Da        Isoelectric Point: 10.5526

>T285681 WP_046853797.1 NZ_LN847264:326357-326647 [Pseudomonas sp. CCOS 191]
MHTLIQTDRYKKWFAALRDARAQARINVRLRRVELGVLGDCKPVGEGVLELRVDYGPGYRVYLARRGYEVILLLAGGDKT
TQARDIKSALKLARDI

Download         Length: 291 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10653.35 Da        Isoelectric Point: 5.0621

>AT285681 WP_046853798.1 NZ_LN847264:326657-326962 [Pseudomonas sp. CCOS 191]
MADLKLTKWDAADHLKTEQDVVLYLEACLEENDPVLLAAALGDIARARGMAQLARDTGLTREGLYKALSAEGNPSLATIM
KVMAALGVRLHAGAVPPQVAG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F7Y1Z8

Antitoxin

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Source
ID
Structure
No matching records found

References