Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2259678..2260261 Replicon chromosome
Accession NZ_LN832559
Organism Paracoccus aminovorans isolate JCM7685

Toxin (Protein)


Gene name hicA Uniprot ID A0A1I3EXS4
Locus tag JCM7685_RS11220 Protein ID WP_074970956.1
Coordinates 2259678..2259932 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1T4LVA5
Locus tag JCM7685_RS11225 Protein ID WP_012090880.1
Coordinates 2259929..2260261 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCM7685_RS11195 2254918..2255802 + 885 WP_074970952.1 prephenate dehydratase -
JCM7685_RS11200 2255819..2256280 - 462 WP_074970954.1 hypothetical protein -
JCM7685_RS11205 2256436..2258295 + 1860 WP_100526071.1 bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase -
JCM7685_RS19890 2258812..2258967 + 156 WP_170848989.1 hypothetical protein -
JCM7685_RS11215 2259139..2259357 + 219 WP_100526072.1 AlpA family phage regulatory protein -
JCM7685_RS20050 2259380..2259664 + 285 Protein_2230 hypothetical protein -
JCM7685_RS11220 2259678..2259932 + 255 WP_074970956.1 type II toxin-antitoxin system HicA family toxin Toxin
JCM7685_RS11225 2259929..2260261 + 333 WP_012090880.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JCM7685_RS11230 2260302..2261920 + 1619 Protein_2233 recombinase family protein -
JCM7685_RS11235 2262003..2262926 - 924 WP_074970957.1 transglutaminase family protein -
JCM7685_RS11240 2263184..2263717 - 534 WP_062563226.1 hypothetical protein -
JCM7685_RS11245 2263795..2263974 - 180 WP_100526073.1 hypothetical protein -
JCM7685_RS11250 2264065..2264817 - 753 WP_197701080.1 transglutaminase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2258740..2272321 13581


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9491.90 Da        Isoelectric Point: 10.5848

>T285679 WP_074970956.1 NZ_LN832559:2259678-2259932 [Paracoccus aminovorans]
MKKRHRATLELIFARPVNGSIRWTDIEALFVSLGAEVSEREGSRVGVFLFGEVRVFHRPHPSPDTDKGAVASIRKWLDEH
GVKP

Download         Length: 255 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12050.68 Da        Isoelectric Point: 4.7543

>AT285679 WP_012090880.1 NZ_LN832559:2259929-2260261 [Paracoccus aminovorans]
MNNVVEINGEKAVIAFDPEIQMLRGEFVGLNGGADFYAESVHDLIEEGRKSLAVYLEMCREKGIEPRRKFSGKFNVRLTP
DDHAAAVIAAAASGKSLNEWIVGTIREAAE

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I3EXS4

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4LVA5

References