Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 1989002..1989762 Replicon chromosome
Accession NZ_LN832559
Organism Paracoccus aminovorans isolate JCM7685

Toxin (Protein)


Gene name ataT Uniprot ID A0A1I3FM65
Locus tag JCM7685_RS09895 Protein ID WP_074971306.1
Coordinates 1989232..1989762 (+) Length 177 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag JCM7685_RS09890 Protein ID WP_197701048.1
Coordinates 1989002..1989244 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCM7685_RS20045 1987260..1987388 - 129 Protein_1966 IS3 family transposase -
JCM7685_RS09885 1987456..1988388 + 933 WP_100526019.1 IS5 family transposase -
JCM7685_RS09890 1989002..1989244 + 243 WP_197701048.1 DUF1778 domain-containing protein Antitoxin
JCM7685_RS09895 1989232..1989762 + 531 WP_074971306.1 GNAT family N-acetyltransferase Toxin
JCM7685_RS09900 1990465..1991193 - 729 WP_028030902.1 IS21-like element helper ATPase IstB -
JCM7685_RS09905 1991193..1992692 - 1500 WP_090271472.1 IS21 family transposase -
JCM7685_RS09910 1992825..1993013 + 189 Protein_1972 DUF4102 domain-containing protein -
JCM7685_RS09915 1993034..1994011 - 978 Protein_1973 IS66 family transposase -
JCM7685_RS09920 1994052..1994465 - 414 Protein_1974 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1979495..1995018 15523
- inside IScluster/Tn - - 1987456..1994414 6958
- inside Prophage - - 1977387..1995018 17631


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(51-151)

Antitoxin

Vibrio phage ICP1, Orf50

(1-79)


Sequences

Toxin        


Download         Length: 177 a.a.        Molecular weight: 19028.73 Da        Isoelectric Point: 5.6523

>T285678 WP_074971306.1 NZ_LN832559:1989232-1989762 [Paracoccus aminovorans]
MAEIVDTPDHPELPLSAPVPLTAEHDLSAFDCGEPALNDWLRHRALKNESRFSRTYVVCAGNRVVGYFCISAGSVERNAA
PGKVRRNAPDLIPVSIIGRLAVSLDHAGKGLGADLLSDALRRIAVASQSIGIGAVLVQAKDEAAKRFYLRCAEFIEYPED
SRTLFLPIETVVAGFD

Download         Length: 531 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9158.53 Da        Isoelectric Point: 8.6594

>AT285678 WP_197701048.1 NZ_LN832559:1989002-1989244 [Paracoccus aminovorans]
MRIETDTRQLIDDAAAVLGKTRTEFMVESARRQAVDVLLDQRLFTLDSERYDAFMQALDNPPAPGPKLKALLRRTPAWQK

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I3FM65

Antitoxin

Source ID Structure

References