Detailed information of TA system TA028567

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParST/RES-TIGR02293
• Location: 146848..147604
• Replicon: plasmid pSTA7437.01
• Accession: NC_019765
• Organism: Stanieria cyanosphaera PCC 7437

Toxin (Protein)

• Gene name: ParT
• Uniprot ID: K9XZT5
• Locus tag: STA7437_RS22800
• Protein ID: WP_015211996.1
• Coordinates: 146848..147339 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: ParS
• Uniprot ID: -
• Locus tag: STA7437_RS25185
• Protein ID: WP_083856896.1
• Coordinates: 147341..147604 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
STA7437_RS25180	142958..143557	-	600	WP_015211991.1	hypothetical protein	-
STA7437_RS22780	144083..144457	+	375	WP_015211992.1	hypothetical protein	-
STA7437_RS22785	144454..145962	+	1509	WP_015211993.1	relaxase/mobilization nuclease domain-containing protein	-
STA7437_RS22790	146011..146520	+	510	WP_015211994.1	hypothetical protein	-
STA7437_RS22795	146541..146831	+	291	WP_015211995.1	hypothetical protein	-
STA7437_RS22800	146848..147339	-	492	WP_015211996.1	RES family NAD+ phosphorylase	Toxin
STA7437_RS25185	147341..147604	-	264	WP_083856896.1	DUF2384 domain-containing protein	Antitoxin
STA7437_RS26705	147620..147760	-	141	WP_171815487.1	hypothetical protein	-
STA7437_RS22810	147916..149073	+	1158	WP_015211997.1	hypothetical protein	-
STA7437_RS22815	149134..149574	+	441	WP_015211998.1	hypothetical protein	-
STA7437_RS22820	149713..149877	+	165	WP_171815488.1	hypothetical protein	-
STA7437_RS22825	149889..150434	+	546	WP_015211999.1	siphovirus Gp157 family protein	-
STA7437_RS22830	150436..150795	+	360	WP_015212000.1	hypothetical protein	-
STA7437_RS22835	150804..150989	+	186	WP_015212001.1	hypothetical protein	-
STA7437_RS22840	150986..151228	+	243	WP_015212002.1	hypothetical protein	-
STA7437_RS22845	151278..151865	+	588	WP_015212003.1	Uma2 family endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..309296	309296

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-152)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (37-84)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 18364.77 Da
• Isoelectric Point: 7.9914

>T28567 WP_015211996.1 NC_019765:c147339-146848 [Stanieria cyanosphaera PCC 7437]
MLLYRIAKSKYANDLSGEGARRAGGRWNYKGTPVVYTADSTALATLETLVHFPLNLTPKNRAISQRSAVRPATIELPDEL
PITTIDLADLPDNWATYPASNQLAEIGNDWIQKQETVAFCVPSSITPNAEGRNYILNPAHPDFTRVRIIKINEYRYDSRL
FER

Nucleotide

• Length: 492 bp

>T28567 NC_019765:c147339-146848 [Stanieria cyanosphaera PCC 7437]
ATGCTGCTGTATCGAATTGCTAAGAGTAAGTATGCTAACGACCTTAGTGGGGAAGGAGCGAGAAGGGCAGGAGGACGCTG
GAATTATAAAGGAACACCAGTAGTATATACTGCCGATTCAACTGCACTGGCTACTTTGGAAACGTTAGTTCACTTTCCTC
TAAATTTAACACCCAAAAACAGAGCGATCTCGCAGAGATCCGCTGTGCGGCCCGCTACTATTGAGTTACCCGACGAACTG
CCAATAACAACGATCGATTTGGCAGACTTACCAGATAATTGGGCTACCTATCCTGCATCAAACCAGTTGGCAGAAATAGG
AAATGATTGGATTCAAAAACAAGAAACGGTTGCTTTCTGCGTCCCATCTTCGATTACTCCCAACGCTGAAGGGCGTAATT
ATATCTTGAATCCAGCTCATCCTGATTTTACAAGAGTAAGGATTATTAAGATAAACGAATATAGGTATGACAGTAGATTG
TTTGAAAGATAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9914.21 Da
• Isoelectric Point: 4.2340

>AT28567 WP_083856896.1 NC_019765:c147604-147341 [Stanieria cyanosphaera PCC 7437]
MHVSERTLQRYSPDKNLSTELSDRVLQIAKVYARSLDVFEEPEITSEWLKQPIVALGNIAPIEYLDTSSGVEIVLDELTR
IEYGVFS

Nucleotide

• Length: 264 bp

>AT28567 NC_019765:c147604-147341 [Stanieria cyanosphaera PCC 7437]
CTGCACGTTTCTGAAAGAACTCTACAGCGTTATAGTCCAGACAAAAACCTTTCTACCGAACTTTCAGATCGGGTGCTTCA
GATAGCTAAGGTTTATGCCAGAAGCTTGGATGTATTTGAAGAGCCAGAAATTACATCTGAGTGGTTGAAACAGCCCATAG
TAGCTTTAGGAAATATAGCCCCCATAGAATATTTGGATACCTCAAGTGGAGTCGAAATAGTTCTCGACGAACTGACGAGA
ATTGAGTACGGAGTATTCTCCTAA

Structures

Toxin

• AlphaFold DB: K9XZT5