Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | rnlAB/RnlA-RnlB |
| Location | 2762222..2763659 | Replicon | chromosome |
| Accession | NZ_LN832404 | ||
| Organism | Escherichia coli K-12 substr. AG100 | ||
Toxin (Protein)
| Gene name | rnlA | Uniprot ID | P52129 |
| Locus tag | EK12AG100_RS13735 | Protein ID | WP_000155570.1 |
| Coordinates | 2762222..2763295 (+) | Length | 358 a.a. |
Antitoxin (Protein)
| Gene name | rnlB | Uniprot ID | P52130 |
| Locus tag | EK12AG100_RS13740 | Protein ID | WP_000461704.1 |
| Coordinates | 2763288..2763659 (+) | Length | 124 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EK12AG100_RS13720 | 2757655..2759844 | - | 2190 | WP_000136402.1 | DEAD/DEAH box helicase | - |
| EK12AG100_RS13725 | 2759841..2761457 | - | 1617 | WP_000445380.1 | anti-bacteriophage protein AbpA | - |
| EK12AG100_RS13730 | 2761817..2762080 | - | 264 | WP_000502050.1 | DUF1524 domain-containing protein | - |
| EK12AG100_RS13735 | 2762222..2763295 | + | 1074 | WP_000155570.1 | type II toxin-antitoxin system toxin mRNA endoribonuclease RnlA | Toxin |
| EK12AG100_RS13740 | 2763288..2763659 | + | 372 | WP_000461704.1 | type II toxin-antitoxin system antitoxin RnlB | Antitoxin |
| EK12AG100_RS13745 | 2764014..2764877 | + | 864 | WP_000787597.1 | GTPase family protein | - |
| EK12AG100_RS13750 | 2764969..2765790 | + | 822 | WP_000197391.1 | DUF945 domain-containing protein | - |
| EK12AG100_RS13755 | 2766007..2766708 | + | 702 | WP_000189409.1 | WYL domain-containing protein | - |
| EK12AG100_RS13760 | 2766749..2766985 | + | 237 | WP_001144029.1 | hypothetical protein | - |
| EK12AG100_RS13765 | 2766985..2767428 | + | 444 | WP_000824222.1 | hypothetical protein | - |
| EK12AG100_RS13770 | 2767452..2767919 | + | 468 | WP_000702495.1 | hypothetical protein | - |
| EK12AG100_RS13775 | 2768144..2768458 | - | 315 | WP_000065803.1 | arsenate reductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 358 a.a. Molecular weight: 40061.13 Da Isoelectric Point: 6.8293
>T285664 WP_000155570.1 NZ_LN832404:2762222-2763295 [Escherichia coli K-12]
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
Download Length: 1074 bp
Antitoxin
Download Length: 124 a.a. Molecular weight: 13664.69 Da Isoelectric Point: 4.2391
>AT285664 WP_000461704.1 NZ_LN832404:2763288-2763659 [Escherichia coli K-12]
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
Download Length: 372 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|