Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2080048..2080879 Replicon chromosome
Accession NZ_LN832404
Organism Escherichia coli K-12 substr. AG100

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag EK12AG100_RS10525 Protein ID WP_000854814.1
Coordinates 2080505..2080879 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID P76364
Locus tag EK12AG100_RS10520 Protein ID WP_001285584.1
Coordinates 2080048..2080416 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EK12AG100_RS10505 2077715..2079247 + 1533 WP_001350525.1 hypothetical protein -
EK12AG100_RS25180 2079244..2079690 + 447 WP_000187523.1 RadC family protein -
EK12AG100_RS10515 2079753..2079974 + 222 WP_000692323.1 DUF987 domain-containing protein -
EK12AG100_RS10520 2080048..2080416 + 369 WP_001285584.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
EK12AG100_RS10525 2080505..2080879 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
EK12AG100_RS10530 2080876..2081070 + 195 WP_000988600.1 hypothetical protein -
EK12AG100_RS25685 2081083..2081196 + 114 WP_001161660.1 DUF957 domain-containing protein -
EK12AG100_RS24020 2081485..2081613 - 129 Protein_2008 transposase domain-containing protein -
EK12AG100_RS10540 2081685..2081867 + 183 WP_001016348.1 hypothetical protein -
EK12AG100_RS10545 2081968..2082297 - 330 WP_000450409.1 DUF496 family protein -
EK12AG100_RS10550 2082469..2083527 - 1059 WP_001200891.1 FUSC family protein -
EK12AG100_RS10555 2083725..2084198 - 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
EK12AG100_RS10560 2084317..2085483 - 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T285662 WP_000854814.1 NZ_LN832404:2080505-2080879 [Escherichia coli K-12]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13651.52 Da        Isoelectric Point: 5.9541

>AT285662 WP_001285584.1 NZ_LN832404:2080048-2080416 [Escherichia coli K-12]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
PDB 2H28
AlphaFold DB A0A1M2E8G6

References