Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1456747..1457245 Replicon chromosome
Accession NZ_LN831051
Organism Streptococcus pneumoniae strain NCTC7465

Toxin (Protein)


Gene name relE Uniprot ID C1CEI0
Locus tag AT689_RS07810 Protein ID WP_001823540.1
Coordinates 1456991..1457245 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag AT689_RS07805 Protein ID WP_012677101.1
Coordinates 1456747..1456989 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT689_RS07785 1452568..1453743 + 1176 WP_000886147.1 A/G-specific adenine glycosylase -
AT689_RS07790 1453799..1454503 + 705 WP_000722076.1 response regulator transcription factor -
AT689_RS07795 1454496..1455845 + 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
AT689_RS07800 1455847..1456656 + 810 WP_001289496.1 MBL fold metallo-hydrolase -
AT689_RS07805 1456747..1456989 + 243 WP_012677101.1 hypothetical protein Antitoxin
AT689_RS07810 1456991..1457245 + 255 WP_001823540.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AT689_RS07815 1457292..1458035 + 744 WP_000725952.1 ion transporter -
AT689_RS07820 1458325..1459311 - 987 WP_000204727.1 L-lactate dehydrogenase -
AT689_RS07825 1459505..1461973 + 2469 WP_001152988.1 DNA gyrase subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10040.76 Da        Isoelectric Point: 10.9371

>T285642 WP_001823540.1 NZ_LN831051:1456991-1457245 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEGPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9204.47 Da        Isoelectric Point: 4.1051

>AT285642 WP_012677101.1 NZ_LN831051:1456747-1456989 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVANLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C1CEI0

Antitoxin

Source ID Structure

References