Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 953076..953738 Replicon chromosome
Accession NZ_LN831051
Organism Streptococcus pneumoniae strain NCTC7465

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AT689_RS05170 Protein ID WP_000192221.1
Coordinates 953076..953249 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag AT689_RS05175 Protein ID WP_000961810.1
Coordinates 953286..953738 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT689_RS05145 949051..950370 + 1320 WP_000502561.1 glycoside hydrolase family 32 protein -
AT689_RS05155 950915..952186 - 1272 WP_001113225.1 replication-associated recombination protein A -
AT689_RS05160 952456..952695 + 240 WP_000818079.1 hypothetical protein -
AT689_RS05165 952685..952933 + 249 WP_000797237.1 hypothetical protein -
AT689_RS05170 953076..953249 + 174 WP_000192221.1 type II toxin-antitoxin system HicA family toxin Toxin
AT689_RS05175 953286..953738 + 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AT689_RS05180 954029..954499 + 471 WP_000257100.1 DUF3013 family protein -
AT689_RS05185 954518..955606 + 1089 WP_000719704.1 M50 family metallopeptidase -
AT689_RS05190 955587..955745 + 159 WP_000418159.1 7,8-dihydro-8-oxoguanine-triphosphatase -
AT689_RS05195 955855..956889 + 1035 WP_000747916.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6368.47 Da        Isoelectric Point: 10.8214

>T285641 WP_000192221.1 NZ_LN831051:953076-953249 [Streptococcus pneumoniae]
MTQKEMVKLLTAHGWIKTRGGKGSHIKIEKQGERPITILHGELNKYTERGIGKQAGL

Download         Length: 174 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT285641 WP_000961810.1 NZ_LN831051:953286-953738 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References