Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5732017..5732658 Replicon chromosome
Accession NZ_LN831039
Organism Mycolicibacterium smegmatis strain NCTC8159

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag AT701_RS27580 Protein ID WP_011730672.1
Coordinates 5732017..5732460 (-) Length 148 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID A0A2U9PXD6
Locus tag AT701_RS27585 Protein ID WP_003897042.1
Coordinates 5732470..5732658 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT701_RS27560 5727498..5728235 + 738 WP_011730668.1 GntR family transcriptional regulator -
AT701_RS27565 5728237..5729769 + 1533 WP_058126982.1 cyclohexanecarboxylate-CoA ligase -
AT701_RS27570 5729770..5730543 + 774 WP_011730670.1 SDR family oxidoreductase -
AT701_RS27575 5730540..5732012 + 1473 WP_058127741.1 long-chain fatty acid--CoA ligase -
AT701_RS27580 5732017..5732460 - 444 WP_011730672.1 SRPBCC family protein Toxin
AT701_RS27585 5732470..5732658 - 189 WP_003897042.1 antitoxin Antitoxin
AT701_RS27590 5732684..5735059 - 2376 WP_058126983.1 cation-translocating P-type ATPase -
AT701_RS27595 5735073..5736680 - 1608 WP_162267879.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-141)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16157.75 Da        Isoelectric Point: 9.9432

>T285640 WP_011730672.1 NZ_LN831039:c5732460-5732017 [Mycolicibacterium smegmatis]
MAKLSVSVEVPLPPEQAWEYASDLSRYHEWLSIHRAWRSKLPETLEKGTVIESIVEVKGMLNRVRWTLVHYKPPQALTLN
GDGRGGVKVKLIGKIKPTDNGATVGFDLHLGGPALFGPIGMVVAAALKSDIQESLNRFKQLYAPSAT

Download         Length: 444 bp

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6886.64 Da        Isoelectric Point: 4.6906

>AT285640 WP_003897042.1 NZ_LN831039:c5732658-5732470 [Mycolicibacterium smegmatis]
MGFLDKAKDLLSQNADKVDTVIDKAGDMIDEKTQGKYAQHVDKAQDAAKNAIRKDDPQEPQQ

Download         Length: 189 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2U9PXD6

References