Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 3569300..3570296 Replicon chromosome
Accession NZ_LN831039
Organism Mycolicibacterium smegmatis strain NCTC8159

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag AT701_RS17180 Protein ID WP_058126279.1
Coordinates 3569718..3570296 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID I7GB97
Locus tag AT701_RS17175 Protein ID WP_003894879.1
Coordinates 3569300..3569692 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT701_RS17155 3564770..3565888 + 1119 WP_003894875.1 acyltransferase -
AT701_RS17160 3566062..3566667 + 606 WP_003894876.1 class I SAM-dependent methyltransferase -
AT701_RS17165 3566669..3568297 - 1629 WP_058126278.1 GMC family oxidoreductase N-terminal domain-containing protein -
AT701_RS17170 3568607..3569236 + 630 WP_003894878.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
AT701_RS17175 3569300..3569692 + 393 WP_003894879.1 hypothetical protein Antitoxin
AT701_RS17180 3569718..3570296 + 579 WP_058126279.1 zeta toxin family protein Toxin
AT701_RS17185 3570308..3571660 - 1353 WP_011729067.1 LysM peptidoglycan-binding domain-containing protein -
AT701_RS35265 3571995..3572150 + 156 WP_003894882.1 hypothetical protein -
AT701_RS17195 3572356..3573744 + 1389 WP_058126280.1 L-serine ammonia-lyase -
AT701_RS17200 3573778..3574338 - 561 WP_058126281.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21118.31 Da        Isoelectric Point: 9.9425

>T285638 WP_058126279.1 NZ_LN831039:3569718-3570296 [Mycolicibacterium smegmatis]
VKRLDLVVGPNGAGKSTFVELTLAPLLTGSAFVNADEIAKRRWPHAPAEHSYDAARIASDTRLKLIELGESFIAETVFSH
PSKLQLIDTAQAAGYTVVMHVVMIPEDLAVLRVQHRVRAGGHHVPEEKIRERHQRLWPLVALAAARADISTFYDNSAVRG
PRIVAQLAGGFAVGRPAWPMWAPQVLTSRWPE

Download         Length: 579 bp

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13841.29 Da        Isoelectric Point: 4.9246

>AT285638 WP_003894879.1 NZ_LN831039:3569300-3569692 [Mycolicibacterium smegmatis]
MTETADRVTRFAADLVESAAAEGARQSRSAKQQLDHWARVGRAVSSQHTAARRRVEAALAGDLALRDLTPEEGVVFNAEI
SAAIEENLAHTDYGQVLAGRGVTTVALDDDGAIVRYQPDGTTTVLAPAQR

Download         Length: 393 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2U9PRP8

References