Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 726775..727472 Replicon chromosome
Accession NZ_LN831039
Organism Mycolicibacterium smegmatis strain NCTC8159

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AT701_RS33990 Protein ID WP_081319354.1
Coordinates 726775..727206 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AT701_RS03170 Protein ID WP_058125156.1
Coordinates 727215..727472 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT701_RS03145 722798..723706 + 909 WP_058125151.1 MBL fold metallo-hydrolase -
AT701_RS03150 723699..725090 + 1392 WP_058125152.1 carboxylesterase/lipase family protein -
AT701_RS03155 725147..725779 - 633 WP_058125153.1 TetR/AcrR family transcriptional regulator -
AT701_RS03160 725858..726763 + 906 WP_058125154.1 DUF2236 domain-containing protein -
AT701_RS33990 726775..727206 - 432 WP_081319354.1 type II toxin-antitoxin system VapC family toxin Toxin
AT701_RS03170 727215..727472 - 258 WP_058125156.1 ribbon-helix-helix protein, CopG family Antitoxin
AT701_RS03175 727571..728473 + 903 WP_058127516.1 class I SAM-dependent methyltransferase -
AT701_RS03180 728603..730429 + 1827 WP_174519565.1 type VII secretion AAA-ATPase EccA -
AT701_RS03185 730426..731982 + 1557 WP_058125158.1 type VII secretion protein EccB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-132)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-39)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15939.08 Da        Isoelectric Point: 6.1461

>T285635 WP_081319354.1 NZ_LN831039:c727206-726775 [Mycolicibacterium smegmatis]
MFLLDVNVVLAAYRADHPDHATVRPWFDRLLDGDGPFTVPVQVWASFLRLVTNRRIFPVPTPRDDAFAFIEAVNGQPHHV
PVSAGPRHLALLHQLCDEGDASGDLIPDAVLAAIAHEHHCDVATLDRDFARFTTVRHLRPSLD

Download         Length: 432 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9140.34 Da        Isoelectric Point: 5.8508

>AT285635 WP_058125156.1 NZ_LN831039:c727472-727215 [Mycolicibacterium smegmatis]
VRTTIAIADELLAAAKRRARQRGQSLGSVIEDALRRELAADQEAAPRPEVPVFTDGTGPRAGIDLRSARALHEVLDEGLD
LNALK

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References