285624

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1925750..1926526 Replicon chromosome
Accession NZ_LN831036
Organism Staphylococcus aureus strain NCTC13435

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag AT694_RS09505 Protein ID WP_000031108.1
Coordinates 1925750..1925902 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag AT694_RS09510 Protein ID WP_001251231.1
Coordinates 1925927..1926526 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT694_RS09490 1921476..1922297 + 822 WP_000669376.1 RluA family pseudouridine synthase -
AT694_RS09495 1922760..1924145 - 1386 WP_000116231.1 class II fumarate hydratase -
AT694_RS09500 1924341..1924736 - 396 WP_000901023.1 hypothetical protein -
AT694_RS09505 1925750..1925902 - 153 WP_000031108.1 hypothetical protein Toxin
AT694_RS09510 1925927..1926526 - 600 WP_001251231.1 glucosamine-6-phosphate isomerase Antitoxin
AT694_RS09515 1926686..1927156 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
AT694_RS09520 1927161..1928288 - 1128 WP_000379986.1 tRNA epoxyqueuosine(34) reductase QueG -
AT694_RS09525 1928439..1929161 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
AT694_RS09530 1929154..1930611 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T285624 WP_000031108.1 NZ_LN831036:c1925902-1925750 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22342.49 Da        Isoelectric Point: 5.3880

>AT285624 WP_001251231.1 NZ_LN831036:c1926526-1925927 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLNELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure

References