Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1550850..1551647 Replicon chromosome
Accession NZ_LN831036
Organism Staphylococcus aureus strain NCTC13435

Toxin (Protein)


Gene name - Uniprot ID A0A641AAS6
Locus tag AT694_RS07580 Protein ID WP_000525006.1
Coordinates 1551186..1551647 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag AT694_RS07575 Protein ID WP_001260486.1
Coordinates 1550850..1551173 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT694_RS07525 1546585..1547142 - 558 WP_000645042.1 DUF2815 family protein -
AT694_RS07530 1547168..1548334 - 1167 WP_000762551.1 DUF2800 domain-containing protein -
AT694_RS07535 1548331..1548693 - 363 WP_000279446.1 hypothetical protein -
AT694_RS07540 1548708..1549031 - 324 WP_000175000.1 hypothetical protein -
AT694_RS07545 1549111..1549272 - 162 WP_001285955.1 DUF1270 family protein -
AT694_RS07550 1549285..1549548 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
AT694_RS07555 1549573..1549788 - 216 WP_001036301.1 hypothetical protein -
AT694_RS07560 1549843..1550208 + 366 WP_001128433.1 hypothetical protein -
AT694_RS07565 1550177..1550422 - 246 WP_001025401.1 DUF2829 domain-containing protein -
AT694_RS07570 1550438..1550686 - 249 WP_000272861.1 helix-turn-helix domain-containing protein -
AT694_RS07575 1550850..1551173 + 324 WP_001260486.1 helix-turn-helix domain-containing protein Antitoxin
AT694_RS07580 1551186..1551647 + 462 WP_000525006.1 hypothetical protein Toxin
AT694_RS07585 1551664..1552098 + 435 WP_001226136.1 hypothetical protein -
AT694_RS07590 1552127..1552522 + 396 WP_000449655.1 hypothetical protein -
AT694_RS07595 1552612..1552758 + 147 WP_001013104.1 hypothetical protein -
AT694_RS07600 1552755..1553369 - 615 WP_000191459.1 hypothetical protein -
AT694_RS14570 1553495..1554701 + 1207 Protein_1455 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukF-PV / lukS-PV 1506153..1572344 66191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18118.47 Da        Isoelectric Point: 4.6915

>T285623 WP_000525006.1 NZ_LN831036:1551186-1551647 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVYRYKEI

Download         Length: 462 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12427.10 Da        Isoelectric Point: 9.3811

>AT285623 WP_001260486.1 NZ_LN831036:1550850-1551173 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641AAS6

Antitoxin

Source ID Structure

References