Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 741712..742349 Replicon chromosome
Accession NZ_LN831035
Organism Haemophilus influenzae strain NCTC8143

Toxin (Protein)


Gene name VapC1 Uniprot ID E4QWH2
Locus tag AT683_RS03755 Protein ID WP_005649049.1
Coordinates 741712..742116 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID E4QWH3
Locus tag AT683_RS03760 Protein ID WP_005649046.1
Coordinates 742113..742349 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT683_RS03725 737272..737838 + 567 WP_005544066.1 elongation factor P -
AT683_RS03735 738189..738776 - 588 WP_005654063.1 primosomal replication protein -
AT683_RS03740 738809..740161 - 1353 WP_005694344.1 Na+/H+ antiporter family protein -
AT683_RS03745 740475..741164 - 690 WP_011271988.1 ribonuclease T -
AT683_RS03750 741238..741645 - 408 WP_005688980.1 lactoylglutathione lyase -
AT683_RS03755 741712..742116 - 405 WP_005649049.1 type II toxin-antitoxin system VapC family toxin Toxin
AT683_RS03760 742113..742349 - 237 WP_005649046.1 antitoxin Antitoxin
AT683_RS03765 742442..743167 - 726 WP_011271987.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
AT683_RS03770 743220..743738 - 519 WP_005649040.1 isoprenylcysteine carboxyl methyltransferase family protein -
AT683_RS03775 743957..745723 + 1767 WP_011271986.1 aspartate--tRNA ligase -
AT683_RS03780 745745..746218 + 474 WP_011271985.1 dihydroneopterin triphosphate diphosphatase -
AT683_RS03785 746230..746970 + 741 WP_005649034.1 YebC/PmpR family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15692.29 Da        Isoelectric Point: 8.9777

>T285617 WP_005649049.1 NZ_LN831035:c742116-741712 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIIAERVSQLLPNDRLVMSFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9037.19 Da        Isoelectric Point: 4.2342

>AT285617 WP_005649046.1 NZ_LN831035:c742349-742113 [Haemophilus influenzae]
MLTKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E4QWH2

Antitoxin

Source ID Structure
AlphaFold DB E4QWH3

References