Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 571963..572441 Replicon chromosome
Accession NZ_LN831035
Organism Haemophilus influenzae strain NCTC8143

Toxin (Protein)


Gene name VapD Uniprot ID Q4QN95
Locus tag AT683_RS02810 Protein ID WP_011272058.1
Coordinates 572163..572441 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q4QN94
Locus tag AT683_RS02805 Protein ID WP_011272059.1
Coordinates 571963..572154 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT683_RS02785 568173..569156 + 984 WP_038440579.1 DNA polymerase III subunit delta' -
AT683_RS02790 569209..569991 + 783 WP_038440581.1 YchF/TatD family DNA exonuclease -
AT683_RS02795 570018..570542 + 525 WP_038440582.1 DUF1523 family protein -
AT683_RS02800 570593..571891 + 1299 WP_005691371.1 hemolysin family protein -
AT683_RS02805 571963..572154 + 192 WP_011272059.1 DUF5397 family protein Antitoxin
AT683_RS02810 572163..572441 + 279 WP_011272058.1 virulence-associated protein VapD Toxin
AT683_RS02815 572534..573064 + 531 WP_038440586.1 hypothetical protein -
AT683_RS02820 573136..574635 + 1500 WP_058222164.1 fused PTS fructose transporter subunit IIA/HPr protein -
AT683_RS02825 574637..575578 + 942 WP_011272055.1 1-phosphofructokinase -
AT683_RS02830 575580..577250 + 1671 WP_058222165.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10647.08 Da        Isoelectric Point: 4.9670

>T285615 WP_011272058.1 NZ_LN831035:572163-572441 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIGAVLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7073.06 Da        Isoelectric Point: 3.8431

>AT285615 WP_011272059.1 NZ_LN831035:571963-572154 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSYLLEDPEAE

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6ZI0
PDB 6ZN8
PDB 6ZI1

Antitoxin

Source ID Structure
PDB 6ZN8
AlphaFold DB Q4QN94

References