Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 377429..377939 Replicon chromosome
Accession NZ_LN831035
Organism Haemophilus influenzae strain NCTC8143

Toxin (Protein)


Gene name toxT Uniprot ID A0A2S9R6L1
Locus tag AT683_RS01820 Protein ID WP_038439526.1
Coordinates 377429..377650 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag AT683_RS01825 Protein ID WP_005650837.1
Coordinates 377643..377939 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT683_RS01815 374281..377322 + 3042 WP_058222155.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
AT683_RS01820 377429..377650 + 222 WP_038439526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AT683_RS01825 377643..377939 + 297 WP_005650837.1 helix-turn-helix transcriptional regulator Antitoxin
AT683_RS01830 378123..380039 + 1917 WP_038440439.1 ABC transporter ATP-binding protein -
AT683_RS01835 380049..380585 + 537 WP_011272152.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
AT683_RS01840 380601..381152 + 552 WP_011272151.1 threonylcarbamoyl-AMP synthase -
AT683_RS01845 381156..381962 + 807 WP_011272150.1 shikimate dehydrogenase -
AT683_RS01850 381974..382726 + 753 WP_011272149.1 DUF3800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(10-63)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-89)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8804.33 Da        Isoelectric Point: 10.7588

>T285614 WP_038439526.1 NZ_LN831035:377429-377650 [Haemophilus influenzae]
VQNLLENQALFAILDGEIWELRPIRDRILFARLMDGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Download         Length: 222 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11092.94 Da        Isoelectric Point: 10.3139

>AT285614 WP_005650837.1 NZ_LN831035:377643-377939 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9R6L1

Antitoxin

Source ID Structure

References