Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 322456..323087 Replicon chromosome
Accession NZ_LN831035
Organism Haemophilus influenzae strain NCTC8143

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag AT683_RS01580 Protein ID WP_058222150.1
Coordinates 322456..322791 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q4QMK8
Locus tag AT683_RS01585 Protein ID WP_005692346.1
Coordinates 322791..323087 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT683_RS01570 317538..318836 - 1299 WP_006995277.1 trigger factor -
AT683_RS01575 319205..322399 + 3195 WP_154590032.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
AT683_RS01580 322456..322791 - 336 WP_058222150.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
AT683_RS01585 322791..323087 - 297 WP_005692346.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AT683_RS01590 323207..324061 - 855 WP_058222151.1 DUF3298 domain-containing protein -
AT683_RS01595 324080..325939 - 1860 WP_058222152.1 selenocysteine-specific translation elongation factor -
AT683_RS01600 325936..327321 - 1386 WP_038440401.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-107)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-93)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13148.92 Da        Isoelectric Point: 4.9104

>T285613 WP_058222150.1 NZ_LN831035:c322791-322456 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCYIQGNLVLIYQYV
IRDEFDEFDEFDEFDELKFSRLNTHSQTALK

Download         Length: 336 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.27 Da        Isoelectric Point: 4.2845

>AT285613 WP_005692346.1 NZ_LN831035:c323087-322791 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q4QMK8

References