Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-UPF0150
Location 2949342..2949776 Replicon chromosome
Accession NC_019753
Organism Crinalium epipsammum PCC 9333

Toxin (Protein)


Gene name hicA Uniprot ID K9W245
Locus tag CRI9333_RS12850 Protein ID WP_015203599.1
Coordinates 2949552..2949776 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID K9W108
Locus tag CRI9333_RS12845 Protein ID WP_015203598.1
Coordinates 2949342..2949548 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRI9333_RS12835 2945089..2947017 - 1929 WP_015203596.1 cyclomaltodextrin glucanotransferase -
CRI9333_RS12840 2947365..2949068 - 1704 WP_015203597.1 NAD(P)H-quinone oxidoreductase subunit 4 -
CRI9333_RS12845 2949342..2949548 + 207 WP_015203598.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CRI9333_RS12850 2949552..2949776 + 225 WP_015203599.1 type II toxin-antitoxin system HicA family toxin Toxin
CRI9333_RS24935 2949953..2950807 - 855 WP_051035378.1 GIY-YIG nuclease family protein -
CRI9333_RS12860 2950930..2951187 + 258 WP_015203601.1 hypothetical protein -
CRI9333_RS12865 2951303..2952415 + 1113 Protein_2621 ISL3 family transposase -
CRI9333_RS25715 2952605..2953054 - 450 Protein_2622 hypothetical protein -
CRI9333_RS12875 2953150..2953803 + 654 WP_015203603.1 hypothetical protein -
CRI9333_RS27380 2953817..2954728 + 912 WP_015203604.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-65)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-58)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8157.46 Da        Isoelectric Point: 7.2032

>T28561 WP_015203599.1 NC_019753:2949552-2949776 [Crinalium epipsammum PCC 9333]
MSSNLPVLSGDEVVRVFEKFGWQFVRQSASHMIMVKEGEQVTLSIPDHKEVAKGTLRSLIRAAGLTVQEFVGAI

Download         Length: 225 bp

>T28561 NC_019753:2949552-2949776 [Crinalium epipsammum PCC 9333]
ATGTCATCTAATCTACCTGTGCTTAGTGGGGATGAGGTAGTTCGTGTGTTTGAAAAGTTTGGCTGGCAGTTTGTACGGCA
GAGTGCAAGCCACATGATTATGGTCAAAGAAGGTGAACAAGTAACACTGTCTATTCCAGATCACAAGGAAGTAGCGAAAG
GCACTTTACGCAGTCTCATTCGCGCGGCTGGGCTGACTGTGCAAGAGTTCGTTGGTGCAATTTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7534.59 Da        Isoelectric Point: 4.3599

>AT28561 WP_015203598.1 NC_019753:2949342-2949548 [Crinalium epipsammum PCC 9333]
MRFNVTIDRDEDGVWIVECPSIPGCVSQGETKEKALENIHDAIAACLQVRAERGLPLTIETHQVEVMA

Download         Length: 207 bp

>AT28561 NC_019753:2949342-2949548 [Crinalium epipsammum PCC 9333]
ATGAGGTTCAATGTAACGATTGACCGTGATGAGGATGGTGTGTGGATTGTGGAGTGTCCCAGCATCCCAGGATGTGTTAG
TCAAGGTGAGACTAAAGAAAAAGCTTTAGAAAATATTCACGATGCGATCGCTGCTTGTCTTCAAGTTCGAGCAGAACGTG
GATTGCCACTTACAATAGAAACCCATCAGGTAGAGGTTATGGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K9W245

Antitoxin

Source ID Structure
AlphaFold DB K9W108

References