285608

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1191136..1192178 Replicon chromosome
Accession NZ_LN831029
Organism Achromobacter xylosoxidans strain NCTC10807

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A0D6GAF2
Locus tag AT699_RS05515 Protein ID WP_058207229.1
Coordinates 1191136..1191711 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A972JB12
Locus tag AT699_RS05520 Protein ID WP_024067903.1
Coordinates 1191708..1192178 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT699_RS05485 1186633..1187535 + 903 WP_024067896.1 bacteriophage abortive infection AbiH family protein -
AT699_RS05490 1187577..1188302 - 726 WP_024067897.1 CBASS effector endonuclease NucC -
AT699_RS05495 1188339..1189241 - 903 WP_024067898.1 nucleotidyltransferase domain-containing protein -
AT699_RS05500 1189241..1189741 - 501 WP_024067899.1 hypothetical protein -
AT699_RS05505 1189738..1190208 - 471 WP_024067900.1 hypothetical protein -
AT699_RS05510 1190205..1191119 - 915 WP_024067901.1 AAA family ATPase -
AT699_RS05515 1191136..1191711 - 576 WP_058207229.1 PIN domain-containing protein Toxin
AT699_RS05520 1191708..1192178 - 471 WP_024067903.1 helix-turn-helix domain-containing protein Antitoxin
AT699_RS05525 1192381..1192764 + 384 WP_024067904.1 RAQPRD family integrative conjugative element protein -
AT699_RS05530 1192761..1192994 + 234 WP_013520781.1 TIGR03758 family integrating conjugative element protein -
AT699_RS05535 1193011..1193370 + 360 WP_024067905.1 TIGR03745 family integrating conjugative element membrane protein -
AT699_RS05540 1193384..1193782 + 399 WP_058207559.1 TIGR03750 family conjugal transfer protein -
AT699_RS05545 1193779..1194477 + 699 WP_024067907.1 TIGR03746 family integrating conjugative element protein -
AT699_RS05550 1194474..1195412 + 939 WP_024067908.1 TIGR03749 family integrating conjugative element protein -
AT699_RS05555 1195402..1196823 + 1422 WP_024067909.1 TIGR03752 family integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1135861..1251380 115519


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

SinI-like, DNA-binding domain

(85-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21576.73 Da        Isoelectric Point: 5.2880

>T285608 WP_058207229.1 NZ_LN831029:c1191711-1191136 [Achromobacter xylosoxidans]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLIKRPDLNRAQVDRTSDLMDRAIPDGVVEGY
EELVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNELLAAYGIEAQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDCFLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17225.63 Da        Isoelectric Point: 6.3803

>AT285608 WP_024067903.1 NZ_LN831029:c1192178-1191708 [Achromobacter xylosoxidans]
MTTTAAQSKMTLPAAAEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHLVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6GAF2

Antitoxin

Source ID Structure

References