Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-Axe/YoeB-RelB
Location 2352696..2353203 Replicon chromosome
Accession NZ_LN831027
Organism Fusobacterium nucleatum subsp. polymorphum strain NCTC10562

Toxin (Protein)


Gene name yoeB Uniprot ID A5TSP0
Locus tag AT688_RS11365 Protein ID WP_005895377.1
Coordinates 2352696..2352956 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID U7TRN8
Locus tag AT688_RS11370 Protein ID WP_005892688.1
Coordinates 2352949..2353203 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT688_RS11335 2347856..2349136 - 1281 WP_005895391.1 D-alanyl-D-alanine carboxypeptidase -
AT688_RS11340 2349219..2349605 - 387 WP_005895388.1 Fe-S cluster assembly scaffold protein NifU -
AT688_RS11345 2349668..2350864 - 1197 WP_005895386.1 cysteine desulfurase NifS -
AT688_RS11350 2350943..2351593 - 651 WP_005895383.1 endonuclease III -
AT688_RS11355 2351679..2352155 - 477 WP_005895381.1 GNAT family N-acetyltransferase -
AT688_RS11360 2352183..2352686 - 504 WP_005895379.1 GNAT family N-acetyltransferase -
AT688_RS11365 2352696..2352956 - 261 WP_005895377.1 Txe/YoeB family addiction module toxin Toxin
AT688_RS11370 2352949..2353203 - 255 WP_005892688.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AT688_RS11375 2353496..2354704 - 1209 WP_005895373.1 tyrosine--tRNA ligase -
AT688_RS11380 2354697..2355980 - 1284 WP_005895370.1 branched-chain amino acid transport system II carrier protein -
AT688_RS11385 2355982..2356344 - 363 WP_005895366.1 arsenate reductase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10251.77 Da        Isoelectric Point: 9.6749

>T285605 WP_005895377.1 NZ_LN831027:c2352956-2352696 [Fusobacterium nucleatum subsp. polymorphum]
MNNLVWTHKAWQDYLYWQTQDKKTLKKINELVKDIGRNGALNGIGKPEVLKNENAYSRRIDEKNRLVYRIVDGFIWIIAC
KGHYEE

Download         Length: 261 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9824.17 Da        Isoelectric Point: 4.4453

>AT285605 WP_005892688.1 NZ_LN831027:c2353203-2352949 [Fusobacterium nucleatum subsp. polymorphum]
MLAINYTTLRTNLKSYFDKAVDNDEDIIITRKNERNVVLLSLDKYNEFLKAMRNLEYMTKIREGIAELEAGKGEIHDLIE
VDDE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A5TSP0

Antitoxin

Source ID Structure
AlphaFold DB A0A806UAF3

References