Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/Fic-DUF4065
Location 714631..715661 Replicon chromosome
Accession NZ_LN831026
Organism Corynebacterium diphtheriae strain NCTC11397

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag AT687_RS03510 Protein ID WP_014303124.1
Coordinates 714631..715083 (-) Length 151 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A806GUF5
Locus tag AT687_RS03515 Protein ID WP_014318824.1
Coordinates 715095..715661 (-) Length 189 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT687_RS03495 711288..712142 + 855 WP_014303121.1 hypothetical protein -
AT687_RS03500 712135..713043 - 909 WP_014309246.1 DUF1906 domain-containing protein -
AT687_RS03505 713172..714371 - 1200 WP_014318823.1 cation:proton antiporter -
AT687_RS03510 714631..715083 - 453 WP_014303124.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
AT687_RS03515 715095..715661 - 567 WP_014318824.1 SocA family protein Antitoxin
AT687_RS12780 715994..716269 + 276 WP_014309249.1 hypothetical protein -
AT687_RS03535 716941..717216 + 276 WP_014301596.1 hypothetical protein -
AT687_RS03540 717223..717975 + 753 WP_014318826.1 precorrin-6A synthase (deacetylating) -
AT687_RS03545 717994..718251 - 258 WP_010934589.1 mycoredoxin -
AT687_RS03550 718272..718775 - 504 WP_014303129.1 dihydrofolate reductase -
AT687_RS03555 718775..719587 - 813 WP_014318827.1 thymidylate synthase -
AT687_RS03560 719681..720439 - 759 WP_014318828.1 3'(2'),5'-bisphosphate nucleotidase CysQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 714631..725292 10661


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(45-127)

Antitoxin

Antitoxin SocA-like, Panacea domain

(23-116)


Sequences

Toxin        


Download         Length: 151 a.a.        Molecular weight: 16477.60 Da        Isoelectric Point: 7.7987

>T285604 WP_014303124.1 NZ_LN831026:c715083-714631 [Corynebacterium diphtheriae]
VSGNSGASPQDMVNKLVYLSCTLNQECGKRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFGVLLYPTIYDQAAALLF
KLANGHYFQDGNKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD

Download         Length: 453 bp

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 21053.55 Da        Isoelectric Point: 4.5592

>AT285604 WP_014318824.1 NZ_LN831026:c715661-715095 [Corynebacterium diphtheriae]
MISIHDVAARVLELHPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASELRADDDRRVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLGSFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDSLEQAADDVAAENAETLRLLAFI

Download         Length: 567 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806GUF5

References