Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4411008..4412266 Replicon chromosome
Accession NZ_LN831024
Organism Pseudomonas aeruginosa strain NCTC10332

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag AT700_RS20190 Protein ID WP_003163133.1
Coordinates 4411008..4411763 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag AT700_RS20195 Protein ID WP_003086329.1
Coordinates 4411898..4412266 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT700_RS20180 4406180..4408723 + 2544 WP_044263834.1 acyl-homoserine-lactone acylase QuiP -
AT700_RS20185 4408878..4410239 - 1362 WP_003081943.1 DNA recombination protein RmuC -
AT700_RS20190 4411008..4411763 - 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
AT700_RS20195 4411898..4412266 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
AT700_RS20200 4412339..4413625 - 1287 WP_023096923.1 FAD-binding oxidoreductase -
AT700_RS20205 4413681..4415270 - 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
AT700_RS20210 4415349..4415825 + 477 WP_003112531.1 hypothetical protein -
AT700_RS30315 4415828..4416103 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T285600 WP_003163133.1 NZ_LN831024:c4411763-4411008 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT285600 WP_003086329.1 NZ_LN831024:c4412266-4411898 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References