Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3459710..3460931 Replicon chromosome
Accession NZ_LN831024
Organism Pseudomonas aeruginosa strain NCTC10332

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag AT700_RS15740 Protein ID WP_003102740.1
Coordinates 3460353..3460931 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AT700_RS15735 Protein ID WP_003088112.1
Coordinates 3459710..3460264 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT700_RS15710 3455278..3455829 + 552 WP_003450159.1 XRE family transcriptional regulator -
AT700_RS15715 3455826..3456224 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
AT700_RS15720 3456237..3456560 - 324 WP_003102734.1 multidrug efflux SMR transporter -
AT700_RS15725 3456891..3457352 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
AT700_RS15730 3457357..3459552 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
AT700_RS15735 3459710..3460264 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
AT700_RS15740 3460353..3460931 + 579 WP_003102740.1 HD domain-containing protein Toxin
AT700_RS15745 3461040..3462227 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
AT700_RS15750 3462217..3464388 - 2172 WP_048521137.1 type I secretion system permease/ATPase -
AT700_RS15755 3464378..3465655 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T285599 WP_003102740.1 NZ_LN831024:3460353-3460931 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT285599 WP_003088112.1 NZ_LN831024:3459710-3460264 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References