Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1833718..1835226 Replicon chromosome
Accession NZ_LN831024
Organism Pseudomonas aeruginosa strain NCTC10332

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag AT700_RS08455 Protein ID WP_078801548.1
Coordinates 1833718..1834305 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag AT700_RS08460 Protein ID WP_003091607.1
Coordinates 1834372..1835226 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT700_RS08450 1829973..1833452 - 3480 WP_003117605.1 hybrid sensor histidine kinase/response regulator -
AT700_RS08455 1833718..1834305 + 588 WP_078801548.1 GNAT family N-acetyltransferase Toxin
AT700_RS08460 1834372..1835226 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
AT700_RS08465 1835323..1837488 + 2166 WP_003115567.1 TonB-dependent receptor family protein -
AT700_RS08470 1837663..1839537 + 1875 WP_010793244.1 MFS transporter -
AT700_RS08475 1839598..1839807 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21883.20 Da        Isoelectric Point: 9.8676

>T285598 WP_078801548.1 NZ_LN831024:1833718-1834305 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRIVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT285598 WP_003091607.1 NZ_LN831024:1834372-1835226 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References