Detailed information of TA system TA028559

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 1529874..1530319
• Replicon: chromosome
• Accession: NC_019753
• Organism: Crinalium epipsammum PCC 9333

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K9VW98
• Locus tag: CRI9333_RS06500
• Protein ID: WP_015202368.1
• Coordinates: 1529874..1530098 (-)
• Length: 75 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: K9VXL6
• Locus tag: CRI9333_RS06505
• Protein ID: WP_015202369.1
• Coordinates: 1530095..1530319 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CRI9333_RS06480	1524977..1526128	+	1152	WP_015202365.1	transposase	-
CRI9333_RS06485	1526294..1527976	+	1683	WP_041225966.1	dihydroxy-acid dehydratase	-
CRI9333_RS06490	1528249..1529106	-	858	WP_015202367.1	pentapeptide repeat-containing protein	-
CRI9333_RS06495	1529299..1529790	+	492	WP_051035350.1	hypothetical protein	-
CRI9333_RS06500	1529874..1530098	-	225	WP_015202368.1	type II toxin-antitoxin system HicA family toxin	Toxin
CRI9333_RS06505	1530095..1530319	-	225	WP_015202369.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CRI9333_RS06510	1530600..1532237	-	1638	WP_015202370.1	chaperonin GroEL	-
CRI9333_RS06515	1532342..1532653	-	312	WP_015202371.1	co-chaperone GroES	-
CRI9333_RS06520	1532988..1533410	+	423	WP_198013648.1	ferredoxin	-
CRI9333_RS27310	1534069..1535316	-	1248	WP_198013649.1	peptidoglycan DD-metalloendopeptidase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1524977..1526128	1151

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (10-64)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (8-55)

Sequences

Toxin

Protein

• Length: 75 a.a.
• Molecular weight: 8413.71 Da
• Isoelectric Point: 8.6992

>T28559 WP_015202368.1 NC_019753:c1530098-1529874 [Crinalium epipsammum PCC 9333]
MSNIPVLKPQEVVRILESLGFVEVRQKGSHKQFRHEDGRGTTVPFHKGRNISPALLRKIASDIDLTVEEMLEAY

Nucleotide

• Length: 225 bp

>T28559 NC_019753:c1530098-1529874 [Crinalium epipsammum PCC 9333]
ATGAGCAATATACCTGTTCTTAAACCACAGGAAGTTGTTCGTATCTTAGAAAGCTTGGGATTTGTAGAAGTAAGGCAGAA
AGGCTCACATAAACAATTCCGTCATGAGGATGGTCGAGGAACAACTGTTCCGTTTCACAAAGGACGCAATATATCTCCAG
CCCTGCTACGTAAAATTGCCAGTGATATCGATTTAACAGTTGAGGAAATGCTAGAGGCGTATTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8356.46 Da
• Isoelectric Point: 3.9940

>AT28559 WP_015202369.1 NC_019753:c1530319-1530095 [Crinalium epipsammum PCC 9333]
MLSLKTFTAIVEKDIDTNLYVGYVPGFPGAHSQGETLDELQDNLREVIEMLLEDAEPKFQTEFVGTQQIVVQRV

Nucleotide

• Length: 225 bp

>AT28559 NC_019753:c1530319-1530095 [Crinalium epipsammum PCC 9333]
ATGTTGAGCTTAAAAACTTTTACCGCAATTGTTGAAAAAGACATTGACACTAATCTTTATGTTGGTTATGTCCCTGGCTT
TCCAGGGGCGCATTCTCAAGGCGAAACTTTAGACGAATTACAAGATAATTTACGCGAAGTAATTGAAATGCTTTTAGAAG
ATGCAGAACCAAAGTTTCAAACAGAGTTTGTTGGTACACAGCAAATTGTGGTTCAGAGAGTATGA

Structures

Toxin

• AlphaFold DB: K9VW98

Antitoxin

• AlphaFold DB: K9VXL6