Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 12676..13586 Replicon plasmid A
Accession NZ_LN824134
Organism Klebsiella pneumoniae strain MS6671

Toxin (Protein)


Gene name - Uniprot ID A0A2N4Z2R0
Locus tag MS6671_RS26995 Protein ID WP_004197882.1
Coordinates 12676..13146 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J4RLY9
Locus tag MS6671_RS27000 Protein ID WP_004181895.1
Coordinates 13143..13586 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS6671_RS26975 7919..9259 - 1341 WP_004196353.1 ISNCY family transposase -
MS6671_RS26980 9348..10880 + 1533 WP_004118819.1 IS3 family transposase -
MS6671_RS26985 11007..12068 + 1062 WP_060591524.1 IS481 family transposase -
MS6671_RS26990 12306..12566 + 261 WP_004026352.1 hypothetical protein -
MS6671_RS26995 12676..13146 - 471 WP_004197882.1 RES family NAD+ phosphorylase Toxin
MS6671_RS27000 13143..13586 - 444 WP_004181895.1 DUF2384 domain-containing protein Antitoxin
MS6671_RS27005 13687..14958 - 1272 WP_004197886.1 translesion error-prone DNA polymerase V subunit UmuC -
MS6671_RS27010 14958..15380 - 423 WP_004197884.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
MS6671_RS27015 15735..16304 - 570 Protein_18 transposase -
MS6671_RS31080 16306..16521 + 216 Protein_19 IS200/IS605 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..279305 279305


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17633.92 Da        Isoelectric Point: 4.5152

>T285587 WP_004197882.1 NZ_LN824134:c13146-12676 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDFFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16536.87 Da        Isoelectric Point: 10.3013

>AT285587 WP_004181895.1 NZ_LN824134:c13586-13143 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N4Z2R0

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4RLY9

References