Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4522605..4523262 Replicon chromosome
Accession NZ_LN824133
Organism Klebsiella pneumoniae strain MS6671

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag MS6671_RS22445 Protein ID WP_002916310.1
Coordinates 4522605..4523015 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MS6671_RS22450 Protein ID WP_002916312.1
Coordinates 4522996..4523262 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS6671_RS22425 4518605..4520338 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
MS6671_RS22430 4520344..4521057 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MS6671_RS22435 4521080..4521976 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MS6671_RS22440 4522077..4522598 + 522 WP_004144730.1 flavodoxin FldB -
MS6671_RS22445 4522605..4523015 - 411 WP_002916310.1 protein YgfX Toxin
MS6671_RS22450 4522996..4523262 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MS6671_RS22455 4523508..4524491 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
MS6671_RS22460 4524642..4525301 - 660 WP_002916317.1 hemolysin III family protein -
MS6671_RS22465 4525465..4525776 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
MS6671_RS22470 4525826..4526554 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MS6671_RS22475 4526673..4528106 + 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T285584 WP_002916310.1 NZ_LN824133:c4523015-4522605 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT285584 WP_002916312.1 NZ_LN824133:c4523262-4522996 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References