Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3862635..3863278 Replicon chromosome
Accession NZ_LN824133
Organism Klebsiella pneumoniae strain MS6671

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag MS6671_RS19125 Protein ID WP_032433387.1
Coordinates 3862635..3863051 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag MS6671_RS19130 Protein ID WP_001261276.1
Coordinates 3863048..3863278 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS6671_RS19095 3857804..3858007 - 204 WP_032433376.1 hemolysin expression modulator Hha -
MS6671_RS19100 3858067..3858558 - 492 WP_032433378.1 hypothetical protein -
MS6671_RS19105 3858589..3859107 - 519 WP_045326794.1 hypothetical protein -
MS6671_RS19110 3859166..3859414 - 249 WP_032433382.1 hypothetical protein -
MS6671_RS19115 3859733..3861304 + 1572 WP_032433383.1 ATP-binding protein -
MS6671_RS19120 3861499..3862479 - 981 WP_032433385.1 hypothetical protein -
MS6671_RS19125 3862635..3863051 - 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
MS6671_RS19130 3863048..3863278 - 231 WP_001261276.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MS6671_RS19135 3863583..3864398 + 816 WP_032433388.1 hypothetical protein -
MS6671_RS19145 3864926..3867166 - 2241 WP_045326788.1 NTPase -
MS6671_RS19150 3867169..3868256 - 1088 Protein_3678 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3836081..3878642 42561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T285583 WP_032433387.1 NZ_LN824133:c3863051-3862635 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT285583 WP_001261276.1 NZ_LN824133:c3863278-3863048 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References