Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2630659..2632247 Replicon chromosome
Accession NZ_LN824133
Organism Klebsiella pneumoniae strain MS6671

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag MS6671_RS13010 Protein ID WP_002904792.1
Coordinates 2630925..2632247 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag MS6671_RS13005 Protein ID WP_002904790.1
Coordinates 2630659..2630925 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS6671_RS12980 2625689..2626612 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
MS6671_RS12985 2626593..2627747 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
MS6671_RS12990 2628093..2629472 + 1380 WP_032433093.1 purine permease -
MS6671_RS12995 2629450..2629950 + 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
MS6671_RS13000 2629947..2630273 + 327 WP_002904788.1 hydroxyisourate hydrolase -
MS6671_RS13005 2630659..2630925 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
MS6671_RS13010 2630925..2632247 + 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
MS6671_RS13015 2632264..2633556 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
MS6671_RS13020 2633698..2634702 - 1005 WP_032433097.1 type 1 fimbrial protein -
MS6671_RS13025 2634690..2637191 - 2502 WP_032433099.1 fimbrial biogenesis outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T285577 WP_002904792.1 NZ_LN824133:2630925-2632247 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT285577 WP_002904790.1 NZ_LN824133:2630659-2630925 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References