Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 533741..534257 Replicon chromosome
Accession NZ_LN824133
Organism Klebsiella pneumoniae strain MS6671

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag MS6671_RS02680 Protein ID WP_009486548.1
Coordinates 533973..534257 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MS6671_RS02675 Protein ID WP_002886901.1
Coordinates 533741..533983 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS6671_RS02660 529769..530509 + 741 WP_009486551.1 KDGP aldolase family protein -
MS6671_RS02665 530576..531730 + 1155 WP_002886900.1 lactonase family protein -
MS6671_RS02670 531753..533663 + 1911 WP_009486549.1 BglG family transcription antiterminator -
MS6671_RS02675 533741..533983 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MS6671_RS02680 533973..534257 + 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MS6671_RS02685 534261..534725 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MS6671_RS02690 535033..537171 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
MS6671_RS02700 537528..538271 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MS6671_RS32040 538274..538447 - 174 WP_032433782.1 hypothetical protein -
MS6671_RS02710 538532..538840 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T285574 WP_009486548.1 NZ_LN824133:533973-534257 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT285574 WP_002886901.1 NZ_LN824133:533741-533983 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References