Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2000939..2001498 Replicon chromosome
Accession NZ_LN813019
Organism Halomonas sp. R57-5

Toxin (Protein)


Gene name relE Uniprot ID A0A0D6E7I5
Locus tag HALO_RS09115 Protein ID WP_035583936.1
Coordinates 2000939..2001217 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D6E6Z1
Locus tag HALO_RS09120 Protein ID WP_035583934.1
Coordinates 2001214..2001498 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HALO_RS09105 1998624..1999214 - 591 WP_035583939.1 DUF4202 domain-containing protein -
HALO_RS09110 1999382..2000629 - 1248 WP_035583938.1 dicarboxylate/amino acid:cation symporter -
HALO_RS09115 2000939..2001217 - 279 WP_035583936.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HALO_RS09120 2001214..2001498 - 285 WP_035583934.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HALO_RS09125 2001922..2003199 + 1278 WP_035583932.1 serine--tRNA ligase -
HALO_RS09130 2003144..2003998 - 855 WP_050713353.1 SIMPL domain-containing protein -
HALO_RS09135 2004218..2005315 + 1098 WP_035583928.1 AI-2E family transporter -
HALO_RS09140 2005407..2005730 - 324 WP_007113240.1 thioredoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-44)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10864.65 Da        Isoelectric Point: 4.2293

>T285570 WP_035583936.1 NZ_LN813019:c2001217-2000939 [Halomonas sp. R57-5]
MIFWEEESLNDREVIFEFLYEFNPLVAEKTDDMIEAKAENLLEQPMMGVQREGIPGRLLIVPEVSLIISYWVDGPTIRIM
RVLHQKQKFPIE

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11096.40 Da        Isoelectric Point: 8.0921

>AT285570 WP_035583934.1 NZ_LN813019:c2001498-2001214 [Halomonas sp. R57-5]
MDTRIQFRVDEETKRLSQQMAESQGRTLSDACREFTEQLAEQQRKMLSHDTWLTQQVNRAFEKYDEGKASFIDHESAKAH
MAERKAKIRHRATP

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6E7I5

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6E6Z1

References