Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 1598377..1598908 Replicon chromosome
Accession NZ_LN794158
Organism Candidatus Methylopumilus turicensis strain MMS-10A-171

Toxin (Protein)


Gene name relE Uniprot ID A0A0B7J1T1
Locus tag BN1209_RS08085 Protein ID WP_045751719.1
Coordinates 1598627..1598908 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A0B7IWL5
Locus tag BN1209_RS08080 Protein ID WP_045751718.1
Coordinates 1598377..1598640 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN1209_RS08060 1594825..1595277 + 453 WP_045751715.1 dihydroneopterin triphosphate diphosphatase -
BN1209_RS08065 1595288..1596385 + 1098 WP_045752078.1 quinolinate synthase NadA -
BN1209_RS08070 1596404..1597165 + 762 WP_045751716.1 endonuclease/exonuclease/phosphatase family protein -
BN1209_RS08075 1597169..1598326 + 1158 WP_045751717.1 cardiolipin synthase ClsB -
BN1209_RS08080 1598377..1598640 + 264 WP_045751718.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BN1209_RS08085 1598627..1598908 + 282 WP_045751719.1 type II toxin-antitoxin system YafQ family toxin Toxin
BN1209_RS08090 1599084..1599344 - 261 WP_045751720.1 hypothetical protein -
BN1209_RS08095 1599454..1600695 - 1242 WP_045751721.1 hypothetical protein -
BN1209_RS08100 1600738..1601961 - 1224 WP_052661134.1 site-specific integrase -
BN1209_RS08105 1602163..1602435 + 273 WP_045751722.1 BrnT family toxin -
BN1209_RS08110 1602416..1602691 + 276 WP_144402567.1 BrnA antitoxin family protein -
BN1209_RS09190 1602748..1602909 - 162 WP_171816522.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-72)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10845.71 Da        Isoelectric Point: 10.1402

>T285567 WP_045751719.1 NZ_LN794158:1598627-1598908 [Candidatus Methylopumilus turicensis]
MRTIKQTSQFKRDFKRESKGKHKKTLAEDFKAVLILLLSDAALPEKYCDHAMIGNWNDHRNCHIKPDLILMYRLPDVKTL
QLVRLGSHSELSI

Download         Length: 282 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9488.94 Da        Isoelectric Point: 4.5702

>AT285567 WP_045751718.1 NZ_LN794158:1598377-1598640 [Candidatus Methylopumilus turicensis]
MAANAVVRARVNEQIKDEASVVLEAMGLTVSDAFRIMITRIAKEKALPFEPLVPNAETIEAMKEARAGKLQSFNSIDDLM
ADLNANN

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7J1T1

Antitoxin

Source ID Structure
AlphaFold DB A0A0B7IWL5

References