Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpB-mazE/PRK09812-MazE
Location 921985..922591 Replicon chromosome
Accession NZ_LN794158
Organism Candidatus Methylopumilus turicensis strain MMS-10A-171

Toxin (Protein)


Gene name chpB Uniprot ID A0A0B7IUJ0
Locus tag BN1209_RS04640 Protein ID WP_045751162.1
Coordinates 921985..922326 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0B7IZN7
Locus tag BN1209_RS04645 Protein ID WP_045751163.1
Coordinates 922343..922591 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN1209_RS04615 918390..920207 - 1818 WP_045751158.1 ABC transporter ATP-binding protein/permease -
BN1209_RS04625 920579..920812 + 234 WP_045751159.1 VF530 family protein -
BN1209_RS04630 920885..921505 + 621 WP_045751160.1 hypothetical protein -
BN1209_RS04635 921492..921980 + 489 WP_045751161.1 hypothetical protein -
BN1209_RS04640 921985..922326 - 342 WP_045751162.1 type II toxin-antitoxin system ChpB family toxin Toxin
BN1209_RS04645 922343..922591 - 249 WP_045751163.1 hypothetical protein Antitoxin
BN1209_RS04650 922646..924721 - 2076 WP_045751164.1 TonB-dependent receptor -
BN1209_RS04655 924809..926089 + 1281 WP_045751165.1 divalent metal cation transporter -
BN1209_RS09015 926128..926418 - 291 WP_082048394.1 hypothetical protein -
BN1209_RS04660 926433..926849 - 417 WP_045751166.1 phage holin family protein -
BN1209_RS04665 926854..927183 - 330 WP_045751167.1 DUF883 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 11956.78 Da        Isoelectric Point: 4.7718

>T285566 WP_045751162.1 NZ_LN794158:c922326-921985 [Candidatus Methylopumilus turicensis]
MAKFERGDVVRVCLNPTAGRETQGDFRPALVLSSAEVNDLGTAFIAPITQGGDFARFAGFAVSLTATGMETQGVVLVNML
RAVDLVARGAKKIEVAPAYVVEDALARLQAVFE

Download         Length: 342 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8888.38 Da        Isoelectric Point: 10.1555

>AT285566 WP_045751163.1 NZ_LN794158:c922591-922343 [Candidatus Methylopumilus turicensis]
MKTVSIRKQGGAAIMTIPPDILKSLDAGVGSQLILKVQDGVFTATPIKSPPRKHYKLSDLLSQCDKNAPRNAEMAAWDNI
VQ

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7IUJ0

Antitoxin

Source ID Structure
AlphaFold DB A0A0B7IZN7

References