Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 35149..36283 Replicon plasmid II
Accession NZ_LN774770
Organism Lactococcus piscium MKFS47

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag LACPI_RS11875 Protein ID WP_082095487.1
Coordinates 35149..36009 (-) Length 287 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID A0A0D6E0N2
Locus tag LACPI_RS11880 Protein ID WP_047916720.1
Coordinates 36011..36283 (-) Length 91 a.a.

Genomic Context

LACPI_RS11855LACPI_RS11860LACPI_RS12800LACPI_RS11840LACPI_RS11845LACPI_RS11850LACPI_RS11865LACPI_RS11870LACPI_RS11875LACPI_RS11880LACPI_RS11885LACPI_RS11890LACPI_RS11895LACPI_RS11900
Location: 33309..33608 (300 bp)
Type: Others
Protein ID: WP_047916716.1
Location: 33611..33910 (300 bp)
Type: Others
Protein ID: WP_047916717.1
Location: 34974..35132 (159 bp)
Type: Others
Protein ID: WP_157761154.1
Location: 30305..30688 (384 bp)
Type: Others
Protein ID: WP_047916713.1
Location: 30708..31037 (330 bp)
Type: Others
Protein ID: WP_047916714.1
Location: 31054..33024 (1971 bp)
Type: Others
Protein ID: WP_047916715.1
Location: 33887..34180 (294 bp)
Type: Others
Protein ID: WP_047916718.1
Location: 34196..34708 (513 bp)
Type: Others
Protein ID: WP_047916719.1
Location: 35149..36009 (861 bp)
Type: Toxin
Protein ID: WP_082095487.1
Location: 36011..36283 (273 bp)
Type: Antitoxin
Protein ID: WP_047916720.1
Location: 36304..36561 (258 bp)
Type: Others
Protein ID: WP_157761155.1
Location: 36597..36806 (210 bp)
Type: Others
Protein ID: WP_047916722.1
Location: 36911..37768 (858 bp)
Type: Others
Protein ID: WP_047916723.1
Location: 37904..40048 (2145 bp)
Type: Others
Protein ID: WP_047916724.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LACPI_RS1184030305..30688-384WP_047916713.1hypothetical protein-
LACPI_RS1184530708..31037-330WP_047916714.1hypothetical protein-
LACPI_RS1185031054..33024-1971WP_047916715.1MobA/MobL family protein-
LACPI_RS1185533309..33608+300WP_047916716.1hypothetical protein-
LACPI_RS1186033611..33910+300WP_047916717.1hypothetical protein-
LACPI_RS1186533887..34180-294WP_047916718.1hypothetical protein-
LACPI_RS1187034196..34708-513WP_047916719.1molecular chaperone DnaJ-
LACPI_RS1280034974..35132+159WP_157761154.1hypothetical protein-
LACPI_RS1187535149..36009-861WP_082095487.1zeta toxin family proteinToxin
LACPI_RS1188036011..36283-273WP_047916720.1antitoxinAntitoxin
LACPI_RS1188536304..36561-258WP_157761155.1hypothetical protein-
LACPI_RS1189036597..36806-210WP_047916722.1peptide-binding protein-
LACPI_RS1189536911..37768-858WP_047916723.1ParA family protein-
LACPI_RS1190037904..40048-2145WP_047916724.1type IA DNA topoisomerase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideConjugative plasmid--1..5567155671


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-214)

Antitoxin

Bacterial epsilon antitoxin

(4-90)


Sequences

Toxin        


Download         Length: 287 a.a.        Molecular weight: 32281.05 Da        Isoelectric Point: 9.6225

>T285564 WP_082095487.1 NZ_LN774770:c36009-35149 [Lactococcus piscium MKFS47]
MANIVNFSEKQFEDRLEKNIERLTKNRLAVDEPTAFLLSGQPGSGKTSLRSVIDEETKGNAIIIDNDTFKQQHPNFEELA
KIYGKDVVAKVTPYSNQMTEAIINSLSEQGYNLVIEGTGRTTDVPIKTATMLKTKGYQTKMYVMAVPKIKSYLGTIERYE
DMFKRNPLTARATPKQAHDIVVSNLPSNLETLHKTGVFSDIRLYDRQGMKLYSSLETPSVSPKEPLESILNKKVSGKEIQ
STLERVEEKMVQNKHQDTPEFQAIRQKLDRFKPPIPPLPKLPGIGL

Download         Length: 861 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10577.12 Da        Isoelectric Point: 4.4488

>AT285564 WP_047916720.1 NZ_LN774770:c36283-36011 [Lactococcus piscium MKFS47]
MELNYEKTYQIEIINEFSSTVYNRVLNYVLNHELNTKDMTIVESNLLNQLEVAQEVDLFKQSADELKAIDGYWIAMDLYS
KKLLIKQKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0D6E0N2

References