285564

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 35149..36283 Replicon plasmid II
Accession NZ_LN774770
Organism Lactococcus piscium MKFS47

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag LACPI_RS11875 Protein ID WP_082095487.1
Coordinates 35149..36009 (-) Length 287 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID A0A0D6E0N2
Locus tag LACPI_RS11880 Protein ID WP_047916720.1
Coordinates 36011..36283 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LACPI_RS11840 30305..30688 - 384 WP_047916713.1 hypothetical protein -
LACPI_RS11845 30708..31037 - 330 WP_047916714.1 hypothetical protein -
LACPI_RS11850 31054..33024 - 1971 WP_047916715.1 MobA/MobL family protein -
LACPI_RS11855 33309..33608 + 300 WP_047916716.1 hypothetical protein -
LACPI_RS11860 33611..33910 + 300 WP_047916717.1 hypothetical protein -
LACPI_RS11865 33887..34180 - 294 WP_047916718.1 hypothetical protein -
LACPI_RS11870 34196..34708 - 513 WP_047916719.1 molecular chaperone DnaJ -
LACPI_RS12800 34974..35132 + 159 WP_157761154.1 hypothetical protein -
LACPI_RS11875 35149..36009 - 861 WP_082095487.1 zeta toxin family protein Toxin
LACPI_RS11880 36011..36283 - 273 WP_047916720.1 antitoxin Antitoxin
LACPI_RS11885 36304..36561 - 258 WP_157761155.1 hypothetical protein -
LACPI_RS11890 36597..36806 - 210 WP_047916722.1 peptide-binding protein -
LACPI_RS11895 36911..37768 - 858 WP_047916723.1 ParA family protein -
LACPI_RS11900 37904..40048 - 2145 WP_047916724.1 type IA DNA topoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..55671 55671


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-214)

Antitoxin

Bacterial epsilon antitoxin

(4-90)


Sequences

Toxin        


Download         Length: 287 a.a.        Molecular weight: 32281.05 Da        Isoelectric Point: 9.6225

>T285564 WP_082095487.1 NZ_LN774770:c36009-35149 [Lactococcus piscium MKFS47]
MANIVNFSEKQFEDRLEKNIERLTKNRLAVDEPTAFLLSGQPGSGKTSLRSVIDEETKGNAIIIDNDTFKQQHPNFEELA
KIYGKDVVAKVTPYSNQMTEAIINSLSEQGYNLVIEGTGRTTDVPIKTATMLKTKGYQTKMYVMAVPKIKSYLGTIERYE
DMFKRNPLTARATPKQAHDIVVSNLPSNLETLHKTGVFSDIRLYDRQGMKLYSSLETPSVSPKEPLESILNKKVSGKEIQ
STLERVEEKMVQNKHQDTPEFQAIRQKLDRFKPPIPPLPKLPGIGL

Download         Length: 861 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10577.12 Da        Isoelectric Point: 4.4488

>AT285564 WP_047916720.1 NZ_LN774770:c36283-36011 [Lactococcus piscium MKFS47]
MELNYEKTYQIEIINEFSSTVYNRVLNYVLNHELNTKDMTIVESNLLNQLEVAQEVDLFKQSADELKAIDGYWIAMDLYS
KKLLIKQKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6E0N2

References