Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4420775..4421550 Replicon chromosome
Accession NZ_LN681227
Organism Xenorhabdus nematophila AN6/1

Toxin (Protein)


Gene name TacT2 Uniprot ID D3VFY6
Locus tag XNC2_RS19520 Protein ID WP_013185762.1
Coordinates 4421050..4421550 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID N1NS87
Locus tag XNC2_RS19515 Protein ID WP_010846171.1
Coordinates 4420775..4421053 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XNC2_RS19495 4415840..4417468 + 1629 WP_013185758.1 3-hydroxyacyl-CoA dehydrogenase -
XNC2_RS19500 4417461..4417997 + 537 WP_013185759.1 hydroxyphenylacetyl-CoA thioesterase PaaI -
XNC2_RS19505 4417994..4419208 + 1215 WP_013185760.1 3-oxoadipyl-CoA thiolase -
XNC2_RS19510 4419294..4420637 + 1344 WP_013185761.1 phenylacetate--CoA ligase -
XNC2_RS19515 4420775..4421053 + 279 WP_010846171.1 DUF1778 domain-containing protein Antitoxin
XNC2_RS19520 4421050..4421550 + 501 WP_013185762.1 GNAT family N-acetyltransferase Toxin
XNC2_RS19525 4421638..4422579 + 942 WP_013185763.1 phenylacetic acid degradation operon negative regulatory protein PaaX -
XNC2_RS19530 4422922..4423311 - 390 WP_013185764.1 type II toxin-antitoxin system VapC family toxin -
XNC2_RS19535 4423311..4423574 - 264 WP_010846167.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
XNC2_RS19540 4423989..4425029 + 1041 WP_013141539.1 IS481 family transposase -
XNC2_RS22465 4425313..4425890 - 578 Protein_3880 ISAs1 family transposase -
XNC2_RS19555 4425950..4426459 + 510 Protein_3881 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(9-83)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18238.10 Da        Isoelectric Point: 9.0299

>T285561 WP_013185762.1 NZ_LN681227:4421050-4421550 [Xenorhabdus nematophila AN6/1]
MILSAPELLSEHHYREAFNSGVTTLDQWLKNRALKNNLTGASKTYVVCSENRVLAYYSLAASAIVTDSTPGHFRRNMPNP
IPVVVLGRLAVDRSLQRKGIGRALVQDAALRIIQAADLIGVRGMIIHALSDEVKSFYETIGFEPSPLDPMLLMATLADLK
RSCTNS

Download         Length: 501 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10587.22 Da        Isoelectric Point: 6.3606

>AT285561 WP_010846171.1 NZ_LN681227:4420775-4421053 [Xenorhabdus nematophila AN6/1]
MQTPKRDTLSIRIKPETRNLIDKAAAIQGKNRTDFVLEAAQRMAEETLLEQAIMTASPEAYAKFLDRLDMPPQPNKQLRE
TMQMETPWGKEL

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3VFY6

Antitoxin

Source ID Structure
AlphaFold DB N1NS87

References