Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 2939248..2939773 Replicon chromosome
Accession NZ_LN681227
Organism Xenorhabdus nematophila AN6/1

Toxin (Protein)


Gene name relE Uniprot ID N1NPN2
Locus tag XNC2_RS12330 Protein ID WP_010848883.1
Coordinates 2939248..2939532 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N1NTS9
Locus tag XNC2_RS12335 Protein ID WP_010848882.1
Coordinates 2939522..2939773 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XNC2_RS12310 2934727..2935659 + 933 Protein_2444 IS66 family transposase -
XNC2_RS20880 2935801..2936922 + 1122 Protein_2445 ISAs1 family transposase -
XNC2_RS12320 2937284..2937820 + 537 WP_013184731.1 gluconokinase -
XNC2_RS12325 2937820..2939157 + 1338 WP_010848884.1 gluconate transporter -
XNC2_RS12330 2939248..2939532 - 285 WP_010848883.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XNC2_RS12335 2939522..2939773 - 252 WP_010848882.1 plasmid stabilization protein Antitoxin
XNC2_RS23495 2939854..2940180 - 327 WP_050986632.1 hypothetical protein -
XNC2_RS12345 2940487..2941575 - 1089 WP_013184732.1 DUF459 domain-containing protein -
XNC2_RS12350 2941562..2942979 - 1418 Protein_2452 MBOAT family protein -
XNC2_RS12355 2943172..2943948 - 777 WP_010848877.1 protein bax -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10934.63 Da        Isoelectric Point: 10.2279

>T285556 WP_010848883.1 NZ_LN681227:c2939532-2939248 [Xenorhabdus nematophila AN6/1]
MTYSLKFEKRALKEWEKLGHPIREQFKKKLSERLENPHISSARLSGRNNLYKIKLCSSGYRLVYEVNDHAIVLLVIAVGK
RSGNQVYSVADERE

Download         Length: 285 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9140.29 Da        Isoelectric Point: 3.9282

>AT285556 WP_010848882.1 NZ_LN681227:c2939773-2939522 [Xenorhabdus nematophila AN6/1]
MSYQILTTIAASITDLKRNPMGTVADGEGGAVAILNRNEPAFYCVPPELYAYYLELAEDAELNHIADERMKSAEFVSVDL
NDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N1NPN2

Antitoxin

Source ID Structure
AlphaFold DB N1NTS9

References