Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 403201..403787 Replicon chromosome
Accession NZ_LN681227
Organism Xenorhabdus nematophila AN6/1

Toxin (Protein)


Gene name mazF Uniprot ID D3VIJ6
Locus tag XNC2_RS02035 Protein ID WP_013183288.1
Coordinates 403458..403787 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID D3VIJ5
Locus tag XNC2_RS02030 Protein ID WP_013183287.1
Coordinates 403201..403458 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XNC2_RS01995 398360..399097 + 738 WP_013183284.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
XNC2_RS02000 399295..399693 + 399 WP_010845247.1 30S ribosomal protein S6 -
XNC2_RS02005 399699..400016 + 318 WP_010845246.1 primosomal replication protein N -
XNC2_RS02010 400021..400248 + 228 WP_010845245.1 30S ribosomal protein S18 -
XNC2_RS02015 400287..400739 + 453 WP_013183285.1 50S ribosomal protein L9 -
XNC2_RS02020 400874..401791 - 918 WP_013183286.1 glycerophosphoryl diester phosphodiesterase -
XNC2_RS02025 402346..402966 + 621 WP_010845240.1 peptidylprolyl isomerase -
XNC2_RS02030 403201..403458 + 258 WP_013183287.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
XNC2_RS02035 403458..403787 + 330 WP_013183288.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
XNC2_RS02040 403957..404700 + 744 WP_010845236.1 3'(2'),5'-bisphosphate nucleotidase CysQ -
XNC2_RS02045 404792..405349 - 558 WP_010845235.1 YtfJ family protein -
XNC2_RS02050 405676..405882 + 207 WP_010845234.1 DUF1107 domain-containing protein -
XNC2_RS02055 405997..407328 - 1332 WP_010845233.1 hemolysin family protein -
XNC2_RS02060 407414..408061 - 648 WP_013183289.1 peptide-methionine (S)-S-oxide reductase MsrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-101)

Antitoxin

SpoVT-AbrB domain

(13-47)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12349.57 Da        Isoelectric Point: 9.9619

>T285549 WP_013183288.1 NZ_LN681227:403458-403787 [Xenorhabdus nematophila AN6/1]
MYIPDKGDIVSLNFDPSAGKEIMKRRPVFVISRKMFNERTGFAVVVPITSTARGMKLEVVLPEEVSVQGSILIHQVKSLD
FSERQVKFIEKAPQYIIDRVTELTKAIIL

Download         Length: 330 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9273.67 Da        Isoelectric Point: 4.5959

>AT285549 WP_013183287.1 NZ_LN681227:403201-403458 [Xenorhabdus nematophila AN6/1]
MTAVVIRQSGGANIVSIPKAIVKTLNLHTGSKLELSIQDNKIVLTPVEEELTLESLLAGSPKECFRVTDEDREWLEANSV
GKEVI

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3VIJ6

Antitoxin

Source ID Structure
AlphaFold DB D3VIJ5

References