Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 349498..350147 Replicon chromosome
Accession NZ_LN681227
Organism Xenorhabdus nematophila AN6/1

Toxin (Protein)


Gene name vagD Uniprot ID D3VI06
Locus tag XNC2_RS01795 Protein ID WP_013183266.1
Coordinates 349722..350147 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID N1NH79
Locus tag XNC2_RS01790 Protein ID WP_010845293.1
Coordinates 349498..349725 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XNC2_RS01775 345259..345975 + 717 WP_013183262.1 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB -
XNC2_RS01780 346022..348196 + 2175 WP_065814196.1 DNA helicase II -
XNC2_RS01785 348285..349235 + 951 WP_010845294.1 magnesium/cobalt transporter CorA -
XNC2_RS01790 349498..349725 + 228 WP_010845293.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
XNC2_RS01795 349722..350147 + 426 WP_013183266.1 type II toxin-antitoxin system VapC family toxin Toxin
XNC2_RS01800 350282..351172 - 891 WP_010845291.1 EamA family transporter RarD -
XNC2_RS22555 351460..351618 - 159 WP_113935524.1 hypothetical protein -
XNC2_RS01805 351667..352152 - 486 WP_013183267.1 thioesterase family protein -
XNC2_RS22020 352335..353072 + 738 Protein_345 phospholipase A -
XNC2_RS01815 353201..355027 + 1827 WP_013183268.1 ATP-dependent DNA helicase RecQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15366.95 Da        Isoelectric Point: 9.2397

>T285548 WP_013183266.1 NZ_LN681227:349722-350147 [Xenorhabdus nematophila AN6/1]
MKTVYMLDTNICSFIMREQPVAVIKQLQRCVMNNHLIVVSAITYAEMRFGAVGKKASPKHIVLVDEFCRRLDKILPWDKS
AVDATTKTKIALAAAGTPIGHNDAAIAGHALSVGATLITNNSREFSRVTGLSLEDWANGLI

Download         Length: 426 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8659.82 Da        Isoelectric Point: 4.3775

>AT285548 WP_010845293.1 NZ_LN681227:349498-349725 [Xenorhabdus nematophila AN6/1]
MRTVAIFKNGNNRAIRLPKDLDFEGVNELEIIREGEAIILRPIKPSWDSFLYEDKADADFLSERPDIVEEGRVNL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3VI06

Antitoxin

Source ID Structure
AlphaFold DB N1NH79

References