Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 882704..883244 Replicon chromosome
Accession NZ_LN681225
Organism Legionella hackeliae strain ATCC 35250

Toxin (Protein)


Gene name mazF Uniprot ID A0A0A8UM42
Locus tag LHA_RS04050 Protein ID WP_045105399.1
Coordinates 882704..883024 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0A8UQY9
Locus tag LHA_RS04055 Protein ID WP_045105400.1
Coordinates 883011..883244 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHA_RS04025 878121..879236 - 1116 WP_045105394.1 hypothetical protein -
LHA_RS04030 879452..880309 + 858 WP_045105395.1 hypothetical protein -
LHA_RS04035 880364..881467 - 1104 WP_045105396.1 hypothetical protein -
LHA_RS04050 882704..883024 - 321 WP_045105399.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LHA_RS04055 883011..883244 - 234 WP_045105400.1 hypothetical protein Antitoxin
LHA_RS04060 884061..884402 + 342 WP_082060279.1 Tn3 family transposase -
LHA_RS04065 884845..885550 - 706 Protein_784 transposase -
LHA_RS15930 885869..886063 + 195 WP_052673579.1 hypothetical protein -
LHA_RS16885 886115..886339 + 225 WP_156413572.1 hypothetical protein -
LHA_RS04075 886787..887767 - 981 WP_045105402.1 serine/threonine protein kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11402.36 Da        Isoelectric Point: 9.8716

>T285542 WP_045105399.1 NZ_LN681225:c883024-882704 [Legionella hackeliae]
MIRGDVYWVNLNPTTGSEINKERPCVLVSATPINKARRTVVVVPLSTSAKAIPPITVAVTCLGKQVVAVCDQIRTIDKSR
LMKSAGNLSASDLDKLDDGLRQVLSL

Download         Length: 321 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8883.28 Da        Isoelectric Point: 5.1848

>AT285542 WP_045105400.1 NZ_LN681225:c883244-883011 [Legionella hackeliae]
MEKILISMSDQLASRMRSTIPARQRSKTIAKLIEKEIEKREKALFECALAVEKDSVLEKEMKDWDITIGDGLNNDSW

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8UM42

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8UQY9

References