Detailed information of TA system TA028554

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 5019090..5019751
• Replicon: chromosome
• Accession: NC_019748
• Organism: Stanieria cyanosphaera PCC 7437

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: STA7437_RS22000
• Protein ID: WP_150109180.1
• Coordinates: 5019090..5019416 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: K9XZI1
• Locus tag: STA7437_RS22005
• Protein ID: WP_015195592.1
• Coordinates: 5019416..5019751 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
STA7437_RS21980	5014230..5014613	+	384	WP_015195587.1	hypothetical protein	-
STA7437_RS21985	5014889..5015068	+	180	WP_015195588.1	hypothetical protein	-
STA7437_RS21990	5015236..5016072	+	837	WP_015195589.1	hypothetical protein	-
STA7437_RS21995	5016346..5018946	+	2601	WP_015195590.1	CHAT domain-containing protein	-
STA7437_RS22000	5019090..5019416	+	327	WP_150109180.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
STA7437_RS22005	5019416..5019751	+	336	WP_015195592.1	helix-turn-helix domain-containing protein	Antitoxin
STA7437_RS22010	5019810..5020592	-	783	WP_015195593.1	DUF928 domain-containing protein	-
STA7437_RS25130	5020652..5021071	-	420	WP_015195594.1	hypothetical protein	-
STA7437_RS22020	5021234..5023180	-	1947	WP_015195595.1	CHASE2 domain-containing protein	-
STA7437_RS22025	5023340..5024002	-	663	WP_015195596.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (8-98)

Antitoxin

• HigA2-like, helix-turn-helix domain (17-95)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12095.85 Da
• Isoelectric Point: 10.1015

>T28554 WP_150109180.1 NC_019748:5019090-5019416 [Stanieria cyanosphaera PCC 7437]
MGDSLKQVKSFPDAVRRDIGSSLYDAQKGDKPDNAKPLKGVGNGIFEIVTRFDSDTYRTVYAIQIGNCIYVLHAFQKKSP
KGIKTAQKDVDLIKKRYKQALEISKESN

Nucleotide

• Length: 327 bp

>T28554 NC_019748:5019090-5019416 [Stanieria cyanosphaera PCC 7437]
ATGGGAGATAGCCTCAAACAAGTCAAAAGCTTCCCAGATGCTGTACGTCGTGATATTGGTTCATCTCTGTATGATGCACA
AAAAGGAGATAAACCAGACAACGCCAAGCCTCTTAAGGGAGTAGGCAATGGAATTTTTGAGATTGTTACACGATTTGACT
CTGATACCTACAGGACGGTTTACGCGATACAAATTGGAAACTGCATTTATGTCCTTCATGCTTTTCAGAAAAAATCGCCC
AAGGGTATAAAGACGGCACAGAAAGATGTCGATTTAATTAAAAAACGTTATAAGCAAGCACTTGAGATCTCGAAGGAGTC
AAACTAA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12850.82 Da
• Isoelectric Point: 5.6927

>AT28554 WP_015195592.1 NC_019748:5019416-5019751 [Stanieria cyanosphaera PCC 7437]
MSEENTPIEFIKSSGNVFEDLDLEDAEELLIRAKLGYTVRQILESRHLKQQEIATLLKIKQPEVSNLMKGKYHLFSEGRL
FGFLNKLEQKIIIQIAQHRTGEPLQDVTLEK

Nucleotide

• Length: 336 bp

>AT28554 NC_019748:5019416-5019751 [Stanieria cyanosphaera PCC 7437]
ATGAGTGAAGAAAACACGCCAATCGAATTTATCAAAAGTAGTGGCAATGTTTTTGAAGATCTGGACTTAGAAGACGCAGA
AGAACTATTGATTCGTGCCAAACTGGGTTATACTGTCCGCCAAATATTAGAAAGTCGTCATTTAAAACAGCAAGAAATTG
CGACTCTTTTGAAGATTAAACAACCAGAAGTATCTAACCTAATGAAAGGTAAGTATCATCTATTTTCTGAAGGTCGCTTA
TTTGGTTTCCTAAATAAACTGGAACAAAAAATAATTATTCAAATTGCTCAACATCGTACTGGAGAACCATTACAAGATGT
TACTTTAGAAAAGTAA

Structures

Antitoxin

• AlphaFold DB: K9XZI1