285522

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1348419..1349335 Replicon chromosome
Accession NZ_LN680001
Organism Bacillus subtilis strain BS34A

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag VV28_RS06835 Protein ID WP_003244695.1
Coordinates 1348589..1349335 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag VV28_RS06830 Protein ID WP_003232646.1
Coordinates 1348419..1348589 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VV28_RS06800 1345282..1345611 + 330 WP_003232660.1 phage-like element PBSX protein XkdW -
VV28_RS06805 1345608..1345772 + 165 WP_003232658.1 XkdX family protein -
VV28_RS06810 1345816..1346655 + 840 WP_003245597.1 phage-like element PBSX protein XepA -
VV28_RS06815 1346708..1346977 + 270 WP_003232655.1 hemolysin XhlA family protein -
VV28_RS06820 1346990..1347253 + 264 WP_003232653.1 phage holin -
VV28_RS06825 1347266..1348159 + 894 WP_003245230.1 N-acetylmuramoyl-L-alanine amidase -
VV28_RS22350 1348196..1348333 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
VV28_RS06830 1348419..1348589 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
VV28_RS06835 1348589..1349335 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
VV28_RS06840 1349445..1350446 - 1002 WP_003232642.1 inorganic phosphate transporter -
VV28_RS06845 1350459..1351076 - 618 WP_003218470.1 DUF47 domain-containing protein -
VV28_RS06850 1351352..1352668 - 1317 WP_003244819.1 serine/threonine exchanger -
VV28_RS06855 1353057..1354007 + 951 WP_003245086.1 ring-cleaving dioxygenase -
VV28_RS22355 1354108..1354254 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T285522 WP_003244695.1 NZ_LN680001:c1349335-1348589 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT285522 WP_003232646.1 NZ_LN680001:c1348589-1348419 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References