285501

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1348416..1349332 Replicon chromosome
Accession NZ_LN649259
Organism Bacillus subtilis strain BS49

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag VV34_RS07155 Protein ID WP_003244695.1
Coordinates 1348586..1349332 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag VV34_RS07150 Protein ID WP_003232646.1
Coordinates 1348416..1348586 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VV34_RS07120 1345279..1345608 + 330 WP_003232660.1 phage-like element PBSX protein XkdW -
VV34_RS07125 1345605..1345769 + 165 WP_003232658.1 XkdX family protein -
VV34_RS07130 1345813..1346652 + 840 WP_003245597.1 phage-like element PBSX protein XepA -
VV34_RS07135 1346705..1346974 + 270 WP_003232655.1 hemolysin XhlA family protein -
VV34_RS07140 1346987..1347250 + 264 WP_003232653.1 phage holin -
VV34_RS07145 1347263..1348156 + 894 WP_003245230.1 N-acetylmuramoyl-L-alanine amidase -
VV34_RS23555 1348193..1348330 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
VV34_RS07150 1348416..1348586 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
VV34_RS07155 1348586..1349332 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
VV34_RS07160 1349442..1350443 - 1002 WP_003232642.1 inorganic phosphate transporter -
VV34_RS07165 1350456..1351073 - 618 WP_003218470.1 DUF47 domain-containing protein -
VV34_RS07170 1351349..1352665 - 1317 WP_003244819.1 serine/threonine exchanger -
VV34_RS07175 1353054..1354004 + 951 WP_003245086.1 ring-cleaving dioxygenase -
VV34_RS23560 1354105..1354251 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T285501 WP_003244695.1 NZ_LN649259:c1349332-1348586 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT285501 WP_003232646.1 NZ_LN649259:c1348586-1348416 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References