Detailed information of TA system TA028550

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 3812500..3812942
• Replicon: chromosome
• Accession: NC_019748
• Organism: Stanieria cyanosphaera PCC 7437

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K9XXP1
• Locus tag: STA7437_RS16525
• Protein ID: WP_015194533.1
• Coordinates: 3812500..3812727 (-)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: STA7437_RS16530
• Protein ID: WP_015194534.1
• Coordinates: 3812727..3812942 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
STA7437_RS16510	3808454..3808864	-	411	WP_015194530.1	hypothetical protein	-
STA7437_RS16515	3808963..3809283	+	321	WP_015194531.1	ribbon-helix-helix protein, CopG family	-
STA7437_RS16520	3809495..3812023	-	2529	WP_015194532.1	glycogen/starch/alpha-glucan phosphorylase	-
STA7437_RS16525	3812500..3812727	-	228	WP_015194533.1	type II toxin-antitoxin system HicA family toxin	Toxin
STA7437_RS16530	3812727..3812942	-	216	WP_015194534.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
STA7437_RS16535	3812961..3813851	-	891	WP_015194535.1	metallophosphoesterase	-
STA7437_RS16540	3813925..3814401	-	477	WP_015194536.1	CRR6 family NdhI maturation factor	-
STA7437_RS16545	3814520..3814954	+	435	WP_015194537.1	transcriptional repressor	-
STA7437_RS16550	3815085..3815516	-	432	WP_015194538.1	hypothetical protein	-
STA7437_RS16555	3816188..3816736	+	549	WP_015194539.1	type 1 glutamine amidotransferase	-
STA7437_RS16560	3816946..3817413	+	468	WP_015194540.1	Orange carotenoid-binding protein	-
STA7437_RS16565	3817461..3817865	+	405	WP_015194541.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (10-65)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (8-58)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8479.18 Da
• Isoelectric Point: 11.1875

>T28550 WP_015194533.1 NC_019748:c3812727-3812500 [Stanieria cyanosphaera PCC 7437]
MPKLPALTGDAVIRVLEKVGFQKIRQKGSHIRMKHIDGRVVTIPIHRGKTIGKGLLRKIIRDAELTQEEFIALLE

Nucleotide

• Length: 228 bp

>T28550 NC_019748:c3812727-3812500 [Stanieria cyanosphaera PCC 7437]
ATGCCAAAATTACCAGCTTTAACAGGTGATGCTGTTATTCGTGTTCTTGAAAAAGTAGGTTTTCAAAAAATTAGACAGAA
AGGAAGTCATATTAGAATGAAACATATTGATGGACGAGTAGTAACTATCCCTATTCATCGTGGTAAAACTATTGGAAAAG
GTTTATTACGCAAAATTATTCGTGATGCTGAACTGACTCAGGAAGAGTTTATAGCATTACTTGAATAA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8230.43 Da
• Isoelectric Point: 3.9490

>AT28550 WP_015194534.1 NC_019748:c3812942-3812727 [Stanieria cyanosphaera PCC 7437]
MSMSKREFYVIIERDEDGYYVGEVPQLKGCYSQGKTIDELMLNMKEVVELCLEDEDNDIMSEFVGVQKLVV

Nucleotide

• Length: 216 bp

>AT28550 NC_019748:c3812942-3812727 [Stanieria cyanosphaera PCC 7437]
ATGAGTATGAGCAAGCGAGAATTTTACGTAATTATTGAAAGAGACGAAGATGGATATTACGTTGGAGAAGTACCTCAATT
GAAAGGCTGTTATAGTCAAGGAAAAACAATTGATGAGTTAATGCTCAATATGAAAGAAGTTGTTGAACTCTGTTTAGAAG
ATGAAGACAATGATATTATGTCGGAGTTTGTAGGCGTTCAAAAATTAGTGGTTTAA

Structures

Toxin

• AlphaFold DB: K9XXP1