Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2182070..2182584 Replicon chromosome
Accession NZ_LN626917
Organism Staphylococcus aureus strain ILRI_Eymole1/1 isolate Staphylococcus aureus isolate ILRI_Eymole1/1

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag SRS_RS11155 Protein ID WP_000581791.1
Coordinates 2182070..2182279 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag SRS_RS11160 Protein ID WP_000138934.1
Coordinates 2182291..2182584 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SRS_RS11135 2177959..2179029 - 1071 WP_000159638.1 D-alanine--D-alanine ligase -
SRS_RS11140 2179347..2180549 + 1203 WP_001109939.1 rod shape-determining protein RodA -
SRS_RS15620 2180710..2181393 - 684 Protein_2114 transposase -
SRS_RS11150 2181805..2181942 - 138 WP_000828354.1 hypothetical protein -
SRS_RS11155 2182070..2182279 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
SRS_RS11160 2182291..2182584 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
SRS_RS11165 2182750..2184234 + 1485 WP_000571560.1 cardiolipin synthase -
SRS_RS11170 2184262..2184909 + 648 WP_001187612.1 HD domain-containing protein -
SRS_RS11180 2185524..2186396 - 873 WP_000725802.1 membrane protein insertase YidC -
SRS_RS11185 2186482..2187123 - 642 WP_045179393.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2180710..2180886 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T285496 WP_000581791.1 NZ_LN626917:c2182279-2182070 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT285496 WP_000138934.1 NZ_LN626917:c2182584-2182291 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References