Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1959891..1960667 Replicon chromosome
Accession NZ_LN626917
Organism Staphylococcus aureus strain ILRI_Eymole1/1 isolate Staphylococcus aureus isolate ILRI_Eymole1/1

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag SRS_RS09875 Protein ID WP_000031108.1
Coordinates 1959891..1960043 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag SRS_RS09880 Protein ID WP_001251219.1
Coordinates 1960068..1960667 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SRS_RS09855 1956036..1956857 + 822 WP_000669380.1 RluA family pseudouridine synthase -
SRS_RS09860 1957313..1958698 - 1386 WP_000116227.1 class II fumarate hydratase -
SRS_RS09865 1958894..1959289 - 396 WP_045179323.1 hypothetical protein -
SRS_RS09875 1959891..1960043 - 153 WP_000031108.1 hypothetical protein Toxin
SRS_RS09880 1960068..1960667 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
SRS_RS09885 1960826..1961296 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
SRS_RS09890 1961301..1962428 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
SRS_RS09895 1962579..1963301 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
SRS_RS09900 1963294..1964751 - 1458 WP_000649898.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T285494 WP_000031108.1 NZ_LN626917:c1960043-1959891 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT285494 WP_001251219.1 NZ_LN626917:c1960667-1960068 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References